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- W2998710953 abstract "Stiff person syndrome (SPS) is a rare neurologic disorder characterised by rigidity of the truncal and proximal limb muscles with intermittent superimposed spasms. It’s unique because it lacks similarity to any other neurologic disorder. Possibly tetanus is the closest related condition with both inhibiting central gamma-aminobutyric (GABA) systems. SPS is extremely rare with less than 20 cases reported from South Asia which has a population of nearly 2 billion. In its classic form, it is associated with the presence of high titres of glutamic acid decarboxylase (GAD) antibodies. Paraneoplastic SPS comprising of around 5% of the patients has been reported with malignancies of the breast, colon, lung, thymus and Hodgkin’s lymphoma. Antibodies against amphiphysin and gephyrin are detected in paraneoplastic SPS. We report a 58 year old Sri Lankan male with SPS with a high GAD antibody titre and classical electro myographic (EMG) changes, who was found to have an underlying carcinoid tumour. We postulate that SPS was a paraneoplastic phenomenon secondary to the carcinoid in this case. Although neurological syndromes such as sensory neuropathy, limbic encephalitis and, myelopathy have been described as paraneoplastic features in carcinoid, we believe this is the first report of SPS associated with carcinoid tumour." @default.
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- W2998710953 date "2019-10-01" @default.
- W2998710953 modified "2023-09-23" @default.
- W2998710953 title "Stiff person syndrome - An unusual paraneoplastic neurological phenomenon in carcinoid tumour" @default.
- W2998710953 doi "https://doi.org/10.1016/j.jns.2019.10.1336" @default.
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