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• W2998717532 abstract "The current pharmacological strategies for the management of anxiety disorders and depression, serious conditions which are gaining greater prevalence worldwide, depend on only two therapeutic classes of mood-stabilizing drugs: Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). Although first line agents with proven efficacy, their clinical success in the management of anxiety disorders and depression is still considered highly complex due to the multifaceted nature of such conditions. Several studies have shown a possible therapeutic target could be found in the form of the Angiotensin-Converting Enzyme [ACE] type 2 (ACE2), Angiotensin [Ang]-(1-7) and Mas receptor pathway of the Renin- Angiotensin System (RAS), which as will be discussed, has been described to exhibit promising therapeutic properties for the management of anxiety disorders and depression. In this article, the literature to describe recent findings related to the role of the RAS in anxiety and depression disorders was briefly revised. The literature used covers a time range from 1988 to 2019 and were acquired from the National Center for Biotechnology Information’s (NCBI) PubMed search engine. The results demonstrated in this review are promising and encourage the development of new research for the treatment of anxiety and depression disorders focusing on the RAS. In conclusion, the ACE2/Ang-(1-7)/Mas pathway may exhibit anxiolytic and anti-depressive effects through many possible biochemical mechanisms both centrally and peripherally, and result in highly promising mental health benefits which justifies further investigation into this system as a possible new therapeutic target in the management of neuropsychiatric disorders, including any as of yet undescribed risk-benefit analysis compared to currently-implemented pharmacological strategies." @default.
• W2998717532 created "2020-01-10" @default.
• W2998717532 creator A5028331102 @default.
• W2998717532 creator A5081196445 @default.
• W2998717532 date "2020-06-09" @default.
• W2998717532 modified "2023-10-14" @default.
• W2998717532 title "Neuropsychiatric Properties of the ACE2/Ang-(1-7)/Mas Pathway: A Brief Review" @default.
• W2998717532 cites W151749654 @default.
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• W2998717532 cites W1979898152 @default.
• W2998717532 cites W1980437561 @default.
• W2998717532 cites W2001526689 @default.
• W2998717532 cites W2002192631 @default.
• W2998717532 cites W2006580899 @default.
• W2998717532 cites W2008870951 @default.
• W2998717532 cites W2020184819 @default.
• W2998717532 cites W2023741805 @default.
• W2998717532 cites W2024758882 @default.
• W2998717532 cites W2027587538 @default.
• W2998717532 cites W2027636389 @default.
• W2998717532 cites W2028439883 @default.
• W2998717532 cites W2030261100 @default.
• W2998717532 cites W2038232427 @default.
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• W2998717532 cites W2048079557 @default.
• W2998717532 cites W2048724816 @default.
• W2998717532 cites W2050148806 @default.
• W2998717532 cites W2052321977 @default.
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• W2998717532 cites W2087769913 @default.
• W2998717532 cites W2089299823 @default.
• W2998717532 cites W2090083198 @default.
• W2998717532 cites W2101489773 @default.
• W2998717532 cites W2102184369 @default.
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• W2998717532 cites W2157800900 @default.
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• W2998717532 cites W2162445261 @default.
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• W2998717532 cites W2169343422 @default.
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• W2998717532 doi "https://doi.org/10.2174/0929866527666191223143230" @default.
• W2998717532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31868143" @default.
• W2998717532 hasPublicationYear "2020" @default.
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