Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998819969> ?p ?o ?g. }
- W2998819969 endingPage "101966" @default.
- W2998819969 startingPage "101966" @default.
- W2998819969 abstract "Anti-angiogenic treatment is an important option that has changed the therapeutic landscape in various tumors, particularly in patients affected by renal cell carcinoma (RCC). Agents that block signaling pathways governing tumor angiogenesis have raised high expectations among clinicians. Vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs) comprise a heterogeneous class of drugs with distinct pharmacological profiles, including potency, selectivity, pharmacokinetics and drug-drug interactions. Among them, tivozanib is one of the last TKIs introduced in the clinical practice; this drug selectively targets VEGFRs, it is characterized by a favorable pharmacokinetics and safety profile and has been approved as first-line treatment for patients with metastatic RCC (mRCC). In this article, we describe the clinical pharmacology of selected VEGFR-TKIs used for the treatment of mRCC, highlighting the relevant differences; moreover we aim to define the main pharmacologic characteristics of these drug." @default.
- W2998819969 created "2020-01-23" @default.
- W2998819969 creator A5018910230 @default.
- W2998819969 creator A5018988150 @default.
- W2998819969 creator A5025529463 @default.
- W2998819969 creator A5030848899 @default.
- W2998819969 creator A5059568057 @default.
- W2998819969 creator A5068107707 @default.
- W2998819969 creator A5071984747 @default.
- W2998819969 creator A5083693387 @default.
- W2998819969 date "2020-03-01" @default.
- W2998819969 modified "2023-10-05" @default.
- W2998819969 title "Optimizing treatment of renal cell carcinoma with VEGFR-TKIs: a comparison of clinical pharmacology and drug-drug interactions of anti-angiogenic drugs" @default.
- W2998819969 cites W1508955841 @default.
- W2998819969 cites W1527544314 @default.
- W2998819969 cites W1840749914 @default.
- W2998819969 cites W1893477900 @default.
- W2998819969 cites W1893627670 @default.
- W2998819969 cites W1915359770 @default.
- W2998819969 cites W1921673654 @default.
- W2998819969 cites W1970666336 @default.
- W2998819969 cites W1976262446 @default.
- W2998819969 cites W1976487307 @default.
- W2998819969 cites W1980174503 @default.
- W2998819969 cites W1984984885 @default.
- W2998819969 cites W1985610919 @default.
- W2998819969 cites W1989153896 @default.
- W2998819969 cites W1994344097 @default.
- W2998819969 cites W2010017650 @default.
- W2998819969 cites W2010528515 @default.
- W2998819969 cites W2023952988 @default.
- W2998819969 cites W2029098899 @default.
- W2998819969 cites W2033240546 @default.
- W2998819969 cites W2041631632 @default.
- W2998819969 cites W2042481179 @default.
- W2998819969 cites W2042867154 @default.
- W2998819969 cites W2043119411 @default.
- W2998819969 cites W2052683946 @default.
- W2998819969 cites W2055294608 @default.
- W2998819969 cites W2055942526 @default.
- W2998819969 cites W2063544208 @default.
- W2998819969 cites W2070202276 @default.
- W2998819969 cites W2083676244 @default.
- W2998819969 cites W2089446707 @default.
- W2998819969 cites W2092439758 @default.
- W2998819969 cites W2093689408 @default.
- W2998819969 cites W2095771928 @default.
- W2998819969 cites W2105396478 @default.
- W2998819969 cites W2105996516 @default.
- W2998819969 cites W2107054830 @default.
- W2998819969 cites W2107908973 @default.
- W2998819969 cites W2108409964 @default.
- W2998819969 cites W2109308320 @default.
- W2998819969 cites W2114991862 @default.
- W2998819969 cites W2117125017 @default.
- W2998819969 cites W2119404465 @default.
- W2998819969 cites W2121648618 @default.
- W2998819969 cites W2121850852 @default.
- W2998819969 cites W2122994164 @default.
- W2998819969 cites W2134131507 @default.
- W2998819969 cites W2143555751 @default.
- W2998819969 cites W2143652624 @default.
- W2998819969 cites W2151600653 @default.
- W2998819969 cites W2153132143 @default.
- W2998819969 cites W2156947598 @default.
- W2998819969 cites W2157975224 @default.
- W2998819969 cites W2159034771 @default.
- W2998819969 cites W2164791849 @default.
- W2998819969 cites W2167093073 @default.
- W2998819969 cites W2234611863 @default.
- W2998819969 cites W2281400124 @default.
- W2998819969 cites W2314388990 @default.
- W2998819969 cites W2481451033 @default.
- W2998819969 cites W2534245149 @default.
- W2998819969 cites W2540957952 @default.
- W2998819969 cites W2554142171 @default.
- W2998819969 cites W2563522215 @default.
- W2998819969 cites W2574575220 @default.
- W2998819969 cites W2586120609 @default.
- W2998819969 cites W2590045009 @default.
- W2998819969 cites W2602493047 @default.
- W2998819969 cites W2605220782 @default.
- W2998819969 cites W2620995130 @default.
- W2998819969 cites W2686373908 @default.
- W2998819969 cites W2729802620 @default.
- W2998819969 cites W2742019806 @default.
- W2998819969 cites W2744129621 @default.
- W2998819969 cites W2760613511 @default.
- W2998819969 cites W2761305788 @default.
- W2998819969 cites W2765957454 @default.
- W2998819969 cites W2770122680 @default.
- W2998819969 cites W2788281232 @default.
- W2998819969 cites W2793940188 @default.
- W2998819969 cites W2801404544 @default.
- W2998819969 cites W2801596150 @default.
- W2998819969 cites W2803991753 @default.
- W2998819969 cites W2806156366 @default.
- W2998819969 cites W2809751127 @default.