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- W2998839829 abstract "Abstract Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen, lysosomal hydrolases promote tissue remodeling when delivered to the extracellular space and cell death when released to the cytosol. Here, we show that spatially and temporally controlled lysosomal leakage contributes to the accurate chromosome segregation in normal mammalian cell division. One or more chromatin-proximal lysosomes leak in the majority of prometaphases, after which active cathepsin B (CTSB) localizes to the metaphase chromatin and cleaves a small subset of histone H3. Stabilization of lysosomal membranes or inhibition of CTSB activity during mitotic entry results in a significant increase in telomere-related chromosome segregation defects, whereas cells and tissues lacking CTSB and cells expressing CTSB-resistant histone H3 accumulate micronuclei and other nuclear defects. These data suggest that lysosomal leakage and chromatin-associated CTSB contribute to proper chromosome segregation and maintenance of genomic integrity." @default.
- W2998839829 created "2020-01-23" @default.
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- W2998839829 date "2020-01-13" @default.
- W2998839829 modified "2023-10-14" @default.
- W2998839829 title "Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation" @default.
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- W2998839829 cites W1970661950 @default.
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- W2998839829 cites W1982592578 @default.
- W2998839829 cites W1989415481 @default.
- W2998839829 cites W1990955438 @default.
- W2998839829 cites W2000614562 @default.
- W2998839829 cites W2004326158 @default.
- W2998839829 cites W2005727437 @default.
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- W2998839829 cites W2006193439 @default.
- W2998839829 cites W2022167776 @default.
- W2998839829 cites W2029783488 @default.
- W2998839829 cites W2030410023 @default.
- W2998839829 cites W2033374599 @default.
- W2998839829 cites W2035353547 @default.
- W2998839829 cites W2035389897 @default.
- W2998839829 cites W2042738284 @default.
- W2998839829 cites W2049631507 @default.
- W2998839829 cites W2053158202 @default.
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- W2998839829 cites W2054929208 @default.
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- W2998839829 cites W2069370434 @default.
- W2998839829 cites W2070026305 @default.
- W2998839829 cites W2070460611 @default.
- W2998839829 cites W2075729810 @default.
- W2998839829 cites W2080278341 @default.
- W2998839829 cites W2095290410 @default.
- W2998839829 cites W2097865892 @default.
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- W2998839829 cites W2102696072 @default.
- W2998839829 cites W2103790898 @default.
- W2998839829 cites W2107736526 @default.
- W2998839829 cites W2108585827 @default.
- W2998839829 cites W2108594676 @default.
- W2998839829 cites W2126483755 @default.
- W2998839829 cites W2129899300 @default.
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- W2998839829 cites W2140915719 @default.
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- W2998839829 cites W2152462290 @default.
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- W2998839829 cites W2162714383 @default.
- W2998839829 cites W2164455918 @default.
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- W2998839829 cites W2318531023 @default.
- W2998839829 cites W2336207627 @default.
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- W2998839829 cites W2488756161 @default.
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- W2998839829 cites W2518834230 @default.
- W2998839829 cites W2563910203 @default.
- W2998839829 cites W2693925639 @default.
- W2998839829 cites W2786720923 @default.
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- W2998839829 doi "https://doi.org/10.1038/s41467-019-14009-0" @default.
- W2998839829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6957743" @default.
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- W2998839829 hasPublicationYear "2020" @default.
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