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- W2998847910 abstract "The number of people aged over 65 is expected to double in the next 30 years. For many, living longer will mean spending more years with the burdens of chronic diseases such as Alzheimer’s disease, cardiovascular disease, and diabetes. Although researchers have made rapid progress in developing geroprotective interventions that target mechanisms of aging and delay or prevent the onset of multiple concurrent age-related diseases, a lack of standardized techniques to assess healthspan in preclinical murine studies has resulted in reduced reproducibility and slow progress. To overcome this, major centers in Europe and the United States skilled in healthspan analysis came together to agree on a toolbox of techniques that can be used to consistently assess the healthspan of mice. Here, we describe the agreed toolbox, which contains protocols for echocardiography, novel object recognition, grip strength, rotarod, glucose tolerance test (GTT) and insulin tolerance test (ITT), body composition, and energy expenditure. The protocols can be performed longitudinally in the same mouse over a period of 4–6 weeks to test how candidate geroprotectors affect cardiac, cognitive, neuromuscular, and metabolic health. A series of techniques (echocardiography, novel object recognition, grip strength, rotarod, glucose and insulin tolerance tests, body composition, and energy expenditure) are used to assess the health of mice." @default.
- W2998847910 created "2020-01-23" @default.
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- W2998847910 date "2020-01-08" @default.
- W2998847910 modified "2023-10-17" @default.
- W2998847910 title "A toolbox for the longitudinal assessment of healthspan in aging mice" @default.
- W2998847910 cites W1498765990 @default.
- W2998847910 cites W1501895867 @default.
- W2998847910 cites W1541192889 @default.
- W2998847910 cites W1572421661 @default.
- W2998847910 cites W1579760417 @default.
- W2998847910 cites W1733611405 @default.
- W2998847910 cites W1932046626 @default.
- W2998847910 cites W1955034947 @default.
- W2998847910 cites W1960796618 @default.
- W2998847910 cites W1960875531 @default.
- W2998847910 cites W1963721982 @default.
- W2998847910 cites W1966037459 @default.
- W2998847910 cites W1967442749 @default.
- W2998847910 cites W1970281475 @default.
- W2998847910 cites W1973003238 @default.
- W2998847910 cites W1978161786 @default.
- W2998847910 cites W1983245960 @default.
- W2998847910 cites W1984305500 @default.
- W2998847910 cites W1989723790 @default.
- W2998847910 cites W1991749464 @default.
- W2998847910 cites W1993406399 @default.
- W2998847910 cites W2001399616 @default.
- W2998847910 cites W2010893957 @default.
- W2998847910 cites W2018679995 @default.
- W2998847910 cites W2019041167 @default.
- W2998847910 cites W2022274452 @default.
- W2998847910 cites W2025133084 @default.
- W2998847910 cites W2025969688 @default.
- W2998847910 cites W2027431314 @default.
- W2998847910 cites W2031759793 @default.
- W2998847910 cites W2037653131 @default.
- W2998847910 cites W2048376025 @default.
- W2998847910 cites W2049599293 @default.
- W2998847910 cites W2055758387 @default.
- W2998847910 cites W2059278059 @default.
- W2998847910 cites W2064695336 @default.
- W2998847910 cites W2071801476 @default.
- W2998847910 cites W2072441360 @default.
- W2998847910 cites W2074183373 @default.
- W2998847910 cites W2076552336 @default.
- W2998847910 cites W2077067158 @default.
- W2998847910 cites W2077209790 @default.
- W2998847910 cites W2077984838 @default.
- W2998847910 cites W2086888830 @default.
- W2998847910 cites W2087406283 @default.
- W2998847910 cites W2098767190 @default.
- W2998847910 cites W2099386421 @default.
- W2998847910 cites W2102485957 @default.
- W2998847910 cites W2104285917 @default.
- W2998847910 cites W2104379885 @default.
- W2998847910 cites W2111912794 @default.
- W2998847910 cites W2112429003 @default.
- W2998847910 cites W2125121177 @default.
- W2998847910 cites W2126297812 @default.
- W2998847910 cites W2126382879 @default.
- W2998847910 cites W2128807350 @default.
- W2998847910 cites W2129099193 @default.
- W2998847910 cites W2129971447 @default.
- W2998847910 cites W2133625272 @default.
- W2998847910 cites W2137331540 @default.
- W2998847910 cites W2140572389 @default.
- W2998847910 cites W2145437687 @default.
- W2998847910 cites W2147348151 @default.
- W2998847910 cites W2148853147 @default.
- W2998847910 cites W2154395283 @default.
- W2998847910 cites W2156506572 @default.
- W2998847910 cites W2157360228 @default.
- W2998847910 cites W2159830207 @default.
- W2998847910 cites W2159974907 @default.
- W2998847910 cites W2162670203 @default.
- W2998847910 cites W2164361361 @default.
- W2998847910 cites W2168144968 @default.
- W2998847910 cites W2196888533 @default.
- W2998847910 cites W2266900518 @default.
- W2998847910 cites W2301706102 @default.
- W2998847910 cites W2304048947 @default.
- W2998847910 cites W2337932523 @default.
- W2998847910 cites W2408643388 @default.
- W2998847910 cites W2410843339 @default.
- W2998847910 cites W2421296032 @default.
- W2998847910 cites W2466033342 @default.