FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998859168> ?p ?o ?g. }

• W2998859168 endingPage "469" @default.
• W2998859168 startingPage "461" @default.
• W2998859168 abstract "BACKGROUNDS: Anaplastic thyroid cancer/ATC is highly lethal malignancy without reliable chemotherapeutic drug. Resveratrol possesses anti-ATC activities but encounters resistance in some cases due to certain unknown reason(s). OBJECTIVE: Because signal transducer and activator of transcription/STAT 3 signaling is critical for ATC cell survival and the main molecular target of resveratrol, its roles in determining the fates of resveratrol-treated ATC cells were investigated here. METHODS: Human THJ-11T, THJ-16 and THJ-21T ATC cell lines were treated by 100 μM resveratrol and their growth, statuses of STAT3 signaling and STAT3-related gene expression were examined. The relevance of STAT3 activation with resveratrol resistance was elucidated using STAT selective inhibitor AG490. Leukemia inhibitory factor/LIF expression and phosphorylated-STAT3/p-STAT3 nuclear translocation in ATC tissues were immunohistochemically analyzed. RESULTS: Resveratrol inhibited proliferation, p-STAT3 nuclear translocation as well as LIF and STAT3 expression of THJ-16T and THJ-21T but not THJ-21T cells which showed LIF upregulation and more frequent p-STAT3 nuclear translocation. AG490 significantly prevent p-STAT3 nuclear translocation, and reversed the resveratrol tolerance of THJ-11T cells. Immonohistochemical staining revealed 14.3% (4/28) of LIF and 3.6% (1/28) of p-STAT3 detection in noncancerous ATC-surrounding tissues, which increased to 89.5% (17/19) and 52.6% (10/19) respectively among ATC specimens. The correlative analysis indicated the relevance of LIF expression and STAT3 activation (r= 0.825; P< 0.01). CONCLUSIONS: The status of STAT3 activation and LIF expression are closely correlated with the therapeutic effect of resveratrol on ATCs. Frequent LIF upregulation and STAT3 activation are the unfavorable factors of ATCs and the potential targets of anti-ATC therapy." @default.
• W2998859168 created "2020-01-23" @default.
• W2998859168 creator A5001354721 @default.
• W2998859168 creator A5001843311 @default.
• W2998859168 creator A5002038517 @default.
• W2998859168 creator A5036424197 @default.
• W2998859168 creator A5046695122 @default.
• W2998859168 creator A5088067517 @default.
• W2998859168 creator A5090559103 @default.
• W2998859168 date "2020-03-31" @default.
• W2998859168 modified "2023-09-25" @default.
• W2998859168 title "STAT3 signaling statuses determine the fate of resveratrol-treated anaplastic thyroid cancer cells" @default.
• W2998859168 cites W1234084919 @default.
• W2998859168 cites W152563620 @default.
• W2998859168 cites W1720744388 @default.
• W2998859168 cites W1959323200 @default.
• W2998859168 cites W1990004382 @default.
• W2998859168 cites W2027044028 @default.
• W2998859168 cites W2038073734 @default.
• W2998859168 cites W2043313378 @default.
• W2998859168 cites W2062384107 @default.
• W2998859168 cites W2089114442 @default.
• W2998859168 cites W2089602144 @default.
• W2998859168 cites W2101879774 @default.
• W2998859168 cites W2113134419 @default.
• W2998859168 cites W2118278569 @default.
• W2998859168 cites W2135987697 @default.
• W2998859168 cites W2178262933 @default.
• W2998859168 cites W2309457331 @default.
• W2998859168 cites W2329045898 @default.
• W2998859168 cites W2409408370 @default.
• W2998859168 cites W2510482925 @default.
• W2998859168 cites W2564746463 @default.
• W2998859168 cites W2753005915 @default.
• W2998859168 cites W2768566750 @default.
• W2998859168 cites W2776681723 @default.
• W2998859168 cites W2792163167 @default.
• W2998859168 cites W2794413581 @default.
• W2998859168 cites W2794703915 @default.
• W2998859168 cites W2809990660 @default.
• W2998859168 cites W2917690333 @default.
• W2998859168 cites W2981956529 @default.
• W2998859168 cites W2982650366 @default.
• W2998859168 doi "https://doi.org/10.3233/cbm-191010" @default.
• W2998859168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31958078" @default.
• W2998859168 hasPublicationYear "2020" @default.
• W2998859168 type Work @default.
• W2998859168 sameAs 2998859168 @default.
• W2998859168 citedByCount "12" @default.
• W2998859168 countsByYear W29988591682020 @default.
• W2998859168 countsByYear W29988591682021 @default.
• W2998859168 countsByYear W29988591682022 @default.
• W2998859168 countsByYear W29988591682023 @default.
• W2998859168 crossrefType "journal-article" @default.
• W2998859168 hasAuthorship W2998859168A5001354721 @default.
• W2998859168 hasAuthorship W2998859168A5001843311 @default.
• W2998859168 hasAuthorship W2998859168A5002038517 @default.
• W2998859168 hasAuthorship W2998859168A5036424197 @default.
• W2998859168 hasAuthorship W2998859168A5046695122 @default.
• W2998859168 hasAuthorship W2998859168A5088067517 @default.
• W2998859168 hasAuthorship W2998859168A5090559103 @default.
• W2998859168 hasConcept C104317684 @default.
• W2998859168 hasConcept C121608353 @default.
• W2998859168 hasConcept C127561419 @default.
• W2998859168 hasConcept C138626823 @default.
• W2998859168 hasConcept C171958077 @default.
• W2998859168 hasConcept C185592680 @default.
• W2998859168 hasConcept C2776816829 @default.
• W2998859168 hasConcept C2778923194 @default.
• W2998859168 hasConcept C2779761222 @default.
• W2998859168 hasConcept C2780256643 @default.
• W2998859168 hasConcept C502942594 @default.
• W2998859168 hasConcept C54355233 @default.
• W2998859168 hasConcept C55493867 @default.
• W2998859168 hasConcept C62478195 @default.
• W2998859168 hasConcept C86803240 @default.
• W2998859168 hasConcept C95444343 @default.
• W2998859168 hasConcept C98274493 @default.
• W2998859168 hasConceptScore W2998859168C104317684 @default.
• W2998859168 hasConceptScore W2998859168C121608353 @default.
• W2998859168 hasConceptScore W2998859168C127561419 @default.
• W2998859168 hasConceptScore W2998859168C138626823 @default.
• W2998859168 hasConceptScore W2998859168C171958077 @default.
• W2998859168 hasConceptScore W2998859168C185592680 @default.
• W2998859168 hasConceptScore W2998859168C2776816829 @default.
• W2998859168 hasConceptScore W2998859168C2778923194 @default.
• W2998859168 hasConceptScore W2998859168C2779761222 @default.
• W2998859168 hasConceptScore W2998859168C2780256643 @default.
• W2998859168 hasConceptScore W2998859168C502942594 @default.
• W2998859168 hasConceptScore W2998859168C54355233 @default.
• W2998859168 hasConceptScore W2998859168C55493867 @default.
• W2998859168 hasConceptScore W2998859168C62478195 @default.
• W2998859168 hasConceptScore W2998859168C86803240 @default.
• W2998859168 hasConceptScore W2998859168C95444343 @default.
• W2998859168 hasConceptScore W2998859168C98274493 @default.
• W2998859168 hasIssue "4" @default.
• W2998859168 hasLocation W29988591681 @default.
• W2998859168 hasLocation W29988591682 @default.

• next