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- W2998862938 abstract "Abstract The laboratory reference strain 630Δ erm of the anaerobic human pathogen Clostridioides difficile is characterized by a remarkable high oxygen tolerance. We show that an amino acid exchange in the DNA binding domain of the hydrogen peroxide sensor PerR results in a constitutive derepression of PerR-controlled genes and thus in an oxidative stress response even under anaerobic conditions. This questions the model status, strain 630Δ erm claims in C. difficile research." @default.
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- W2998862938 date "2020-01-08" @default.
- W2998862938 modified "2023-10-02" @default.
- W2998862938 title "Work horse strain Clostridioides difficile 630Δerm is oblivious to its anaerobic lifestyle" @default.
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- W2998862938 doi "https://doi.org/10.1101/2020.01.07.897181" @default.
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