FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998866548> ?p ?o ?g. }

• W2998866548 abstract "Abstract Background Diabetes mellitus (DM) and chronic cerebral hypoperfusion(CCH)are both risk factors for cognitive impairment. However, whether DM and CCH can synergistically promote cognitive impairment and the related pathological mechanisms remain unknown. Methods To investigate the effect of DM and CCH on cognitive function, rats fed with high-fat diet (HFD) and injected with low-dose streptozotocin (STZ) followed by bilateral common carotid artery occlusion (BCCAO) were induced to mimic DM and CCH in vivo and mouse BV2 microglial cells were exposed to hypoxia and/or high glucose to mimic CCH complicated with DM pathologies in vitro. To further explore the underlying mechanism, TREM-2-specific small interfering RNA and TREM-2 overexpression lentivirus were used to knock out and overexpress TREM-2, respectively. Results Cognitive deficits, neuronal cell death, neuroinflammation with microglial activation, and TREM-2-MAPK signaling were enhanced when DM was superimposed on CCH both in vivo and in vitro. Manipulating TREM-2 expression levels markedly regulated the p38 MAPK signaling and the inflammatory response in vitro. TREM-2 knockout intensified while TREM-2 overexpression suppressed the p38 MAPK signaling and subsequent pro-inflammatory mediator production under high glucose and hypoxia condition. Conclusions These results suggest that TREM-2 negatively regulates p38 MAPK-mediated inflammatory response when DM was synergistically superimposed on CCH and highlight the importance of TREM-2 as a potential target of immune regulation in DM and CCH." @default.
• W2998866548 created "2020-01-23" @default.
• W2998866548 creator A5017953605 @default.
• W2998866548 creator A5018073672 @default.
• W2998866548 creator A5021535823 @default.
• W2998866548 creator A5034395433 @default.
• W2998866548 creator A5035190058 @default.
• W2998866548 creator A5044768581 @default.
• W2998866548 creator A5058305195 @default.
• W2998866548 creator A5066999889 @default.
• W2998866548 creator A5091543149 @default.
• W2998866548 date "2020-01-03" @default.
• W2998866548 modified "2023-10-15" @default.
• W2998866548 title "TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus" @default.
• W2998866548 cites W2000843387 @default.
• W2998866548 cites W2038961236 @default.
• W2998866548 cites W2064407825 @default.
• W2998866548 cites W2093128825 @default.
• W2998866548 cites W2229565311 @default.
• W2998866548 cites W2471977134 @default.
• W2998866548 cites W2536914990 @default.
• W2998866548 cites W2543489193 @default.
• W2998866548 cites W2566998141 @default.
• W2998866548 cites W2568913974 @default.
• W2998866548 cites W2608045778 @default.
• W2998866548 cites W2622501346 @default.
• W2998866548 cites W2624961247 @default.
• W2998866548 cites W2758846139 @default.
• W2998866548 cites W2763928642 @default.
• W2998866548 cites W2776381055 @default.
• W2998866548 cites W2789701709 @default.
• W2998866548 cites W2793897046 @default.
• W2998866548 cites W2803750405 @default.
• W2998866548 cites W2805968246 @default.
• W2998866548 cites W2891943095 @default.
• W2998866548 cites W2896494410 @default.
• W2998866548 cites W2897705081 @default.
• W2998866548 cites W2897857770 @default.
• W2998866548 cites W2911875199 @default.
• W2998866548 cites W2921482002 @default.
• W2998866548 cites W2936108813 @default.
• W2998866548 cites W2950808276 @default.
• W2998866548 cites W2952234462 @default.
• W2998866548 cites W2955894052 @default.
• W2998866548 cites W2958230138 @default.
• W2998866548 cites W2959218190 @default.
• W2998866548 cites W2962137115 @default.
• W2998866548 cites W2963609873 @default.
• W2998866548 cites W2963738854 @default.
• W2998866548 cites W2965745048 @default.
• W2998866548 cites W2967432297 @default.
• W2998866548 cites W2968775432 @default.
• W2998866548 cites W2968789444 @default.
• W2998866548 cites W2969653968 @default.
• W2998866548 cites W2977662739 @default.
• W2998866548 cites W2980009732 @default.
• W2998866548 doi "https://doi.org/10.1186/s12974-019-1688-9" @default.
• W2998866548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6942413" @default.
• W2998866548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31900229" @default.
• W2998866548 hasPublicationYear "2020" @default.
• W2998866548 type Work @default.
• W2998866548 sameAs 2998866548 @default.
• W2998866548 citedByCount "41" @default.
• W2998866548 countsByYear W29988665482020 @default.
• W2998866548 countsByYear W29988665482021 @default.
• W2998866548 countsByYear W29988665482022 @default.
• W2998866548 countsByYear W29988665482023 @default.
• W2998866548 crossrefType "journal-article" @default.
• W2998866548 hasAuthorship W2998866548A5017953605 @default.
• W2998866548 hasAuthorship W2998866548A5018073672 @default.
• W2998866548 hasAuthorship W2998866548A5021535823 @default.
• W2998866548 hasAuthorship W2998866548A5034395433 @default.
• W2998866548 hasAuthorship W2998866548A5035190058 @default.
• W2998866548 hasAuthorship W2998866548A5044768581 @default.
• W2998866548 hasAuthorship W2998866548A5058305195 @default.
• W2998866548 hasAuthorship W2998866548A5066999889 @default.
• W2998866548 hasAuthorship W2998866548A5091543149 @default.
• W2998866548 hasBestOaLocation W29988665481 @default.
• W2998866548 hasConcept C126322002 @default.
• W2998866548 hasConcept C134018914 @default.
• W2998866548 hasConcept C169760540 @default.
• W2998866548 hasConcept C178790620 @default.
• W2998866548 hasConcept C185592680 @default.
• W2998866548 hasConcept C2776914184 @default.
• W2998866548 hasConcept C2779280383 @default.
• W2998866548 hasConcept C2779830541 @default.
• W2998866548 hasConcept C51551487 @default.
• W2998866548 hasConcept C540031477 @default.
• W2998866548 hasConcept C555293320 @default.
• W2998866548 hasConcept C57074206 @default.
• W2998866548 hasConcept C62478195 @default.
• W2998866548 hasConcept C71924100 @default.
• W2998866548 hasConcept C7836513 @default.
• W2998866548 hasConcept C86803240 @default.
• W2998866548 hasConcept C87753298 @default.
• W2998866548 hasConcept C95444343 @default.
• W2998866548 hasConcept C98274493 @default.
• W2998866548 hasConceptScore W2998866548C126322002 @default.
• W2998866548 hasConceptScore W2998866548C134018914 @default.
• W2998866548 hasConceptScore W2998866548C169760540 @default.

• next