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• W2998887397 endingPage "e0224715" @default.
• W2998887397 startingPage "e0224715" @default.
• W2998887397 abstract "Habits are automated behaviors that are insensitive to changes in behavioral outcomes. Habitual responding is thought to be mediated by the striatum, with medial striatum guiding goal-directed action and lateral striatum promoting habits. However, interspersed throughout the striatum are neurochemically differing subcompartments known as patches, which are characterized by distinct molecular profiles relative to the surrounding matrix tissue. These structures have been thoroughly characterized neurochemically and anatomically, but little is known regarding their function. Patches have been shown to be selectively activated during inflexible motor stereotypies elicited by stimulants, suggesting that patches may subserve habitual behaviors. To explore this possibility, we utilized transgenic mice (Sepw1 NP67) preferentially expressing Cre recombinase in striatal patch neurons to target these neurons for ablation with a virus driving Cre-dependent expression of caspase 3. Mice were then trained to press a lever for sucrose rewards on a variable interval schedule to elicit habitual responding. Mice were not impaired on the acquisition of this task, but lesioning striatal patches disrupted behavioral stability across training, and lesioned mice utilized a more goal-directed behavioral strategy during training. Similarly, when mice were forced to omit responses to receive sucrose rewards, habitual responding was impaired in lesioned mice. To rule out effects of lesion on motor behaviors, mice were then tested for impairments in motor learning on a rotarod and locomotion in an open field. We found that patch lesions partially impaired initial performance on the rotarod without modifying locomotor behaviors in open field. This work indicates that patches promote behavioral stability and habitual responding, adding to a growing literature implicating striatal patches in stimulus-response behaviors." @default.
• W2998887397 created "2020-01-23" @default.
• W2998887397 creator A5009003417 @default.
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• W2998887397 date "2020-01-08" @default.
• W2998887397 modified "2023-10-06" @default.
• W2998887397 title "Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability" @default.
• W2998887397 cites W1522286249 @default.
• W2998887397 cites W1554715089 @default.
• W2998887397 cites W1921515037 @default.
• W2998887397 cites W1971037745 @default.
• W2998887397 cites W1977658700 @default.
• W2998887397 cites W1981451757 @default.
• W2998887397 cites W1981739486 @default.
• W2998887397 cites W1984132513 @default.
• W2998887397 cites W1988699227 @default.
• W2998887397 cites W1991115771 @default.
• W2998887397 cites W1992154604 @default.
• W2998887397 cites W1992587213 @default.
• W2998887397 cites W1993109240 @default.
• W2998887397 cites W1997128521 @default.
• W2998887397 cites W2001898186 @default.
• W2998887397 cites W2002616855 @default.
• W2998887397 cites W2006746363 @default.
• W2998887397 cites W2007031350 @default.
• W2998887397 cites W2007217284 @default.
• W2998887397 cites W2016174164 @default.
• W2998887397 cites W2023741295 @default.
• W2998887397 cites W2026547228 @default.
• W2998887397 cites W2035725055 @default.
• W2998887397 cites W2039051284 @default.
• W2998887397 cites W2046606605 @default.
• W2998887397 cites W2047701828 @default.
• W2998887397 cites W2054043917 @default.
• W2998887397 cites W2055785971 @default.
• W2998887397 cites W2057029832 @default.
• W2998887397 cites W2059004970 @default.
• W2998887397 cites W2065786707 @default.
• W2998887397 cites W2070801122 @default.
• W2998887397 cites W2073837249 @default.
• W2998887397 cites W2074114058 @default.
• W2998887397 cites W2075268859 @default.
• W2998887397 cites W2083537735 @default.
• W2998887397 cites W2085272589 @default.
• W2998887397 cites W2085553767 @default.
• W2998887397 cites W2096240659 @default.
• W2998887397 cites W2103768739 @default.
• W2998887397 cites W2105496648 @default.
• W2998887397 cites W2112337921 @default.
• W2998887397 cites W2115998792 @default.
• W2998887397 cites W2116831623 @default.
• W2998887397 cites W2118691301 @default.
• W2998887397 cites W2120101916 @default.
• W2998887397 cites W2121370521 @default.
• W2998887397 cites W2122076586 @default.
• W2998887397 cites W2128252744 @default.
• W2998887397 cites W2130856357 @default.
• W2998887397 cites W2132182674 @default.
• W2998887397 cites W2132439203 @default.
• W2998887397 cites W2133191097 @default.
• W2998887397 cites W2133351239 @default.
• W2998887397 cites W2142150505 @default.
• W2998887397 cites W2146676986 @default.
• W2998887397 cites W2149207985 @default.
• W2998887397 cites W2156315378 @default.
• W2998887397 cites W2160668068 @default.
• W2998887397 cites W2164158899 @default.
• W2998887397 cites W2167495346 @default.
• W2998887397 cites W2256644786 @default.
• W2998887397 cites W2274685343 @default.
• W2998887397 cites W2338430142 @default.
• W2998887397 cites W2341624030 @default.
• W2998887397 cites W2406024906 @default.
• W2998887397 cites W2504071612 @default.
• W2998887397 cites W2508875940 @default.
• W2998887397 cites W2709271766 @default.
• W2998887397 cites W2752128106 @default.
• W2998887397 cites W2768620954 @default.
• W2998887397 cites W2778797065 @default.
• W2998887397 cites W2785874930 @default.
• W2998887397 cites W2790069474 @default.
• W2998887397 cites W2809845497 @default.
• W2998887397 cites W2889130891 @default.
• W2998887397 cites W2899870041 @default.
• W2998887397 cites W2962937102 @default.
• W2998887397 cites W2985251923 @default.
• W2998887397 cites W4232217111 @default.
• W2998887397 cites W4248803756 @default.
• W2998887397 cites W780748993 @default.
• W2998887397 doi "https://doi.org/10.1371/journal.pone.0224715" @default.
• W2998887397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6948820" @default.
• W2998887397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31914121" @default.
• W2998887397 hasPublicationYear "2020" @default.
• W2998887397 type Work @default.
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