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• W2998889620 abstract "Abstract Background and aims The risk allele (G) of rs10830963 in the melatonin receptor 1B (MTNR1B) gene presents an association with obesity. We study the effect of this SNP on cardiovascular risk factors and weight loss secondary to 2 hypocaloric diets. Methods 361 obese subjects were randomly allocated during 3 months (diet M – high monounsaturated fat hypocaloric diet vs. diet P – high polyunsaturated fat hypocaloric diet). Anthropometric parameters, fasting blood glucose, C-reactive protein (CRP), insulin concentration, insulin resistance (HOMA-IR), lipid profile and adipocytokines levels were measured. Genotype of MTNR1B gene polymorphism (rs10830963) was evaluated. Results All anthropometric parameters, systolic blood pressure and leptin levels decreased in all subjects after both diets. This improvement of anthropometric parameters was higher in non G allele carriers than G allele carriers. After dietary intervention with diet M (CC vs. CG + GG); total cholesterol (delta: −10.4 ± 2.1 mg/dl vs. −6.4 ± 1.2 mg/dl: p  Conclusions Our study detected a relationship of rs10830963 MTNR1B SNP with body weight loss and insulin resistance modification induced by 2 different hypocaloric. Only monounsaturated enriched hypocaloric diet and in no-G allele carriers showed a significant effect on lipoproteins." @default.
• W2998889620 created "2020-01-23" @default.
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• W2998889620 date "2020-01-01" @default.
• W2998889620 modified "2023-10-16" @default.
• W2998889620 title "Dietary-fat effect of the rs10830963 polymorphism in MTNR1B on insulin resistance in response to 3 months weight-loss diets" @default.
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• W2998889620 doi "https://doi.org/10.1016/j.endien.2019.12.004" @default.
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