Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998889719> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2998889719 endingPage "F688" @default.
- W2998889719 startingPage "F683" @default.
- W2998889719 abstract "Exaggerated activation of the renin-angiotensin-aldosterone system (RAAS) is a key feature in diseases such as hypertension, diabetes, and chronic kidney disease. Recently, an intracellular RAAS was demonstrated with angiotensin II (ANG II) type 1 (AT 1 ) and type 2 (AT 2 ) receptors expressed in nuclei and mitochondria. Diabetes is associated with both mitochondrial dysfunction and increased intracellular ANG II concentration in the kidney cortex. The present study investigated the role of ANG II signaling in kidney cortex mitochondria isolated from control and streptozotocin-induced diabetic rats. Mitochondrial oxygen consumption was evaluated after addition of ANG II alone or after preincubation with candesartan (AT 1 receptor antagonist), PD-123319 (AT 2 receptor antagonist), or the two in combination. ANG II binds to only mitochondrial AT 2 receptors in control rats and both AT 1 receptors and AT 2 receptors in diabetic rats. ANG II decreased oxygen consumption in mitochondria from both control and diabetic rats. ANG II response was reversed to increased oxygen consumption by the nitric oxide synthase inhibitor N-nitro-l-arginine methyl ester. AT 1 receptor inhibition did not affect the response to ANG II, whereas AT 2 receptor inhibition abolished the response in mitochondria from control rats and reversed the response to increased oxygen consumption through superoxide-induced mitochondrial uncoupling in mitochondria from diabetic rats. ANG II decrease mitochondrial respiration via AT 2 receptor-mediated nitric oxide release in both control and diabetic rats. AT 1 receptors do not regulate mitochondria function in control rats, whereas ANG II via AT 1 receptors increase mitochondria leak respiration in diabetic animals." @default.
- W2998889719 created "2020-01-23" @default.
- W2998889719 creator A5032153513 @default.
- W2998889719 creator A5047772842 @default.
- W2998889719 date "2020-03-01" @default.
- W2998889719 modified "2023-09-25" @default.
- W2998889719 title "Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats" @default.
- W2998889719 cites W1565367515 @default.
- W2998889719 cites W1985990986 @default.
- W2998889719 cites W2006999079 @default.
- W2998889719 cites W2035637304 @default.
- W2998889719 cites W2036573181 @default.
- W2998889719 cites W2041235216 @default.
- W2998889719 cites W2048843963 @default.
- W2998889719 cites W2053221811 @default.
- W2998889719 cites W2067095056 @default.
- W2998889719 cites W2078959937 @default.
- W2998889719 cites W2083985618 @default.
- W2998889719 cites W2084502320 @default.
- W2998889719 cites W2098328780 @default.
- W2998889719 cites W2111780029 @default.
- W2998889719 cites W2112333460 @default.
- W2998889719 cites W2118316104 @default.
- W2998889719 cites W2124728251 @default.
- W2998889719 cites W2148289342 @default.
- W2998889719 cites W2162190889 @default.
- W2998889719 cites W2166662752 @default.
- W2998889719 cites W2172010034 @default.
- W2998889719 cites W2534662402 @default.
- W2998889719 cites W2791693089 @default.
- W2998889719 cites W2805528464 @default.
- W2998889719 doi "https://doi.org/10.1152/ajprenal.00417.2019" @default.
- W2998889719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31904285" @default.
- W2998889719 hasPublicationYear "2020" @default.
- W2998889719 type Work @default.
- W2998889719 sameAs 2998889719 @default.
- W2998889719 citedByCount "15" @default.
- W2998889719 countsByYear W29988897192020 @default.
- W2998889719 countsByYear W29988897192021 @default.
- W2998889719 countsByYear W29988897192022 @default.
- W2998889719 countsByYear W29988897192023 @default.
- W2998889719 crossrefType "journal-article" @default.
- W2998889719 hasAuthorship W2998889719A5032153513 @default.
- W2998889719 hasAuthorship W2998889719A5047772842 @default.
- W2998889719 hasBestOaLocation W29988897191 @default.
- W2998889719 hasConcept C126322002 @default.
- W2998889719 hasConcept C134018914 @default.
- W2998889719 hasConcept C170493617 @default.
- W2998889719 hasConcept C185592680 @default.
- W2998889719 hasConcept C198710026 @default.
- W2998889719 hasConcept C2777622882 @default.
- W2998889719 hasConcept C2780036600 @default.
- W2998889719 hasConcept C2780091579 @default.
- W2998889719 hasConcept C28859421 @default.
- W2998889719 hasConcept C2908929049 @default.
- W2998889719 hasConcept C519581460 @default.
- W2998889719 hasConcept C55493867 @default.
- W2998889719 hasConcept C71924100 @default.
- W2998889719 hasConcept C84393581 @default.
- W2998889719 hasConcept C86803240 @default.
- W2998889719 hasConceptScore W2998889719C126322002 @default.
- W2998889719 hasConceptScore W2998889719C134018914 @default.
- W2998889719 hasConceptScore W2998889719C170493617 @default.
- W2998889719 hasConceptScore W2998889719C185592680 @default.
- W2998889719 hasConceptScore W2998889719C198710026 @default.
- W2998889719 hasConceptScore W2998889719C2777622882 @default.
- W2998889719 hasConceptScore W2998889719C2780036600 @default.
- W2998889719 hasConceptScore W2998889719C2780091579 @default.
- W2998889719 hasConceptScore W2998889719C28859421 @default.
- W2998889719 hasConceptScore W2998889719C2908929049 @default.
- W2998889719 hasConceptScore W2998889719C519581460 @default.
- W2998889719 hasConceptScore W2998889719C55493867 @default.
- W2998889719 hasConceptScore W2998889719C71924100 @default.
- W2998889719 hasConceptScore W2998889719C84393581 @default.
- W2998889719 hasConceptScore W2998889719C86803240 @default.
- W2998889719 hasFunder F4320306550 @default.
- W2998889719 hasFunder F4320322128 @default.
- W2998889719 hasIssue "3" @default.
- W2998889719 hasLocation W29988897191 @default.
- W2998889719 hasLocation W29988897192 @default.
- W2998889719 hasOpenAccess W2998889719 @default.
- W2998889719 hasPrimaryLocation W29988897191 @default.
- W2998889719 hasRelatedWork W2016647631 @default.
- W2998889719 hasRelatedWork W2034583712 @default.
- W2998889719 hasRelatedWork W2041164650 @default.
- W2998889719 hasRelatedWork W2042660006 @default.
- W2998889719 hasRelatedWork W2044747643 @default.
- W2998889719 hasRelatedWork W2047608102 @default.
- W2998889719 hasRelatedWork W2063619316 @default.
- W2998889719 hasRelatedWork W2077998387 @default.
- W2998889719 hasRelatedWork W2126797993 @default.
- W2998889719 hasRelatedWork W2151139437 @default.
- W2998889719 hasVolume "318" @default.
- W2998889719 isParatext "false" @default.
- W2998889719 isRetracted "false" @default.
- W2998889719 magId "2998889719" @default.
- W2998889719 workType "article" @default.