FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998905211> ?p ?o ?g. }

• W2998905211 endingPage "344" @default.
• W2998905211 startingPage "331" @default.
• W2998905211 abstract "The interaction of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs has been implicated in various types of cancers, including esophageal cancer (EC). The current study aimed to investigate the role of AGAP2-AS1/miR-195-5p/Fos-like antigen-1 (FOSL1) in EC progression. The expression of AGAP2-AS1, miR-195-5p, and FOSL1 in tumor tissues isolated from EC patients and EC cell lines was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), the results of which illustrated that AGAP2-AS1 and FOSL1 were increased while miR-195-5p was reduced in EC. Next, the ectopic expression, knockdown, and reporter assay experiments were all employed to elucidate the mechanism of AGAP2-AS1/miR-195-5p/FOSL1 in the processes of EC cell proliferation, cell cycle, apoptosis, invasion, and migration as well as tumor growth. Knockdown of AGAP2-AS1 or overexpression of miR-195-5p reduced EC cell proliferation, migration, and invasion, blocked cell cycle entry, and elevated apoptosis. FOSL1 was found to be specifically targeted by miR-195-5p. AGAP2-AS1 was observed to upregulate FOSL1 by binding to miR-195-5p. Silencing of AGAP2-AS1 was observed to restrain the development of EC both in vitro and in vivo through upregulating miR-195-5p and downregulating FOSL1. Taken together, AGAP2-AS1 knockdown exercises suppressive effects on the development of EC through miR-195-5p-dependent downregulation of FOSL1. Therefore, targeting AGAP2-AS1 could be a future direction to develop a novel molecule-targeted therapeutic strategy for EC. The interaction of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs has been implicated in various types of cancers, including esophageal cancer (EC). The current study aimed to investigate the role of AGAP2-AS1/miR-195-5p/Fos-like antigen-1 (FOSL1) in EC progression. The expression of AGAP2-AS1, miR-195-5p, and FOSL1 in tumor tissues isolated from EC patients and EC cell lines was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), the results of which illustrated that AGAP2-AS1 and FOSL1 were increased while miR-195-5p was reduced in EC. Next, the ectopic expression, knockdown, and reporter assay experiments were all employed to elucidate the mechanism of AGAP2-AS1/miR-195-5p/FOSL1 in the processes of EC cell proliferation, cell cycle, apoptosis, invasion, and migration as well as tumor growth. Knockdown of AGAP2-AS1 or overexpression of miR-195-5p reduced EC cell proliferation, migration, and invasion, blocked cell cycle entry, and elevated apoptosis. FOSL1 was found to be specifically targeted by miR-195-5p. AGAP2-AS1 was observed to upregulate FOSL1 by binding to miR-195-5p. Silencing of AGAP2-AS1 was observed to restrain the development of EC both in vitro and in vivo through upregulating miR-195-5p and downregulating FOSL1. Taken together, AGAP2-AS1 knockdown exercises suppressive effects on the development of EC through miR-195-5p-dependent downregulation of FOSL1. Therefore, targeting AGAP2-AS1 could be a future direction to develop a novel molecule-targeted therapeutic strategy for EC." @default.
• W2998905211 created "2020-01-23" @default.
• W2998905211 creator A5006011642 @default.
• W2998905211 creator A5017100408 @default.
• W2998905211 creator A5024386153 @default.
• W2998905211 creator A5026627210 @default.
• W2998905211 creator A5060139382 @default.
• W2998905211 creator A5076776163 @default.
• W2998905211 creator A5088409632 @default.
• W2998905211 date "2020-06-01" @default.
• W2998905211 modified "2023-10-15" @default.
• W2998905211 title "Silencing lncRNA AGAP2-AS1 Upregulates miR-195-5p to Repress Migration and Invasion of EC Cells via the Decrease of FOSL1 Expression" @default.
• W2998905211 cites W1542128806 @default.
• W2998905211 cites W1931923002 @default.
• W2998905211 cites W1968935385 @default.
• W2998905211 cites W1969019471 @default.
• W2998905211 cites W1973804607 @default.
• W2998905211 cites W1998174484 @default.
• W2998905211 cites W2020610342 @default.
• W2998905211 cites W2024058161 @default.
• W2998905211 cites W2099567806 @default.
• W2998905211 cites W2105390653 @default.
• W2998905211 cites W2159675211 @default.
• W2998905211 cites W2192593726 @default.
• W2998905211 cites W2405024754 @default.
• W2998905211 cites W2413133207 @default.
• W2998905211 cites W2530515403 @default.
• W2998905211 cites W2563470051 @default.
• W2998905211 cites W2588995065 @default.
• W2998905211 cites W2593759473 @default.
• W2998905211 cites W2601685197 @default.
• W2998905211 cites W2607268158 @default.
• W2998905211 cites W2614560052 @default.
• W2998905211 cites W2705982889 @default.
• W2998905211 cites W2765621378 @default.
• W2998905211 cites W2767632547 @default.
• W2998905211 cites W2782190664 @default.
• W2998905211 cites W2782949733 @default.
• W2998905211 cites W2789475629 @default.
• W2998905211 cites W2792552450 @default.
• W2998905211 cites W2889368816 @default.
• W2998905211 cites W2905022771 @default.
• W2998905211 cites W2909146001 @default.
• W2998905211 cites W2911188335 @default.
• W2998905211 cites W2949674037 @default.
• W2998905211 cites W2959270393 @default.
• W2998905211 cites W2962699104 @default.
• W2998905211 cites W4211048478 @default.
• W2998905211 doi "https://doi.org/10.1016/j.omtn.2019.12.036" @default.
• W2998905211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7082499" @default.
• W2998905211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32199129" @default.
• W2998905211 hasPublicationYear "2020" @default.
• W2998905211 type Work @default.
• W2998905211 sameAs 2998905211 @default.
• W2998905211 citedByCount "35" @default.
• W2998905211 countsByYear W29989052112020 @default.
• W2998905211 countsByYear W29989052112021 @default.
• W2998905211 countsByYear W29989052112022 @default.
• W2998905211 countsByYear W29989052112023 @default.
• W2998905211 crossrefType "journal-article" @default.
• W2998905211 hasAuthorship W2998905211A5006011642 @default.
• W2998905211 hasAuthorship W2998905211A5017100408 @default.
• W2998905211 hasAuthorship W2998905211A5024386153 @default.
• W2998905211 hasAuthorship W2998905211A5026627210 @default.
• W2998905211 hasAuthorship W2998905211A5060139382 @default.
• W2998905211 hasAuthorship W2998905211A5076776163 @default.
• W2998905211 hasAuthorship W2998905211A5088409632 @default.
• W2998905211 hasBestOaLocation W29989052111 @default.
• W2998905211 hasConcept C104317684 @default.
• W2998905211 hasConcept C119056186 @default.
• W2998905211 hasConcept C127561419 @default.
• W2998905211 hasConcept C145059251 @default.
• W2998905211 hasConcept C1491633281 @default.
• W2998905211 hasConcept C173396325 @default.
• W2998905211 hasConcept C190283241 @default.
• W2998905211 hasConcept C29537977 @default.
• W2998905211 hasConcept C502942594 @default.
• W2998905211 hasConcept C54355233 @default.
• W2998905211 hasConcept C62112901 @default.
• W2998905211 hasConcept C81885089 @default.
• W2998905211 hasConcept C86803240 @default.
• W2998905211 hasConcept C95444343 @default.
• W2998905211 hasConcept C97037327 @default.
• W2998905211 hasConceptScore W2998905211C104317684 @default.
• W2998905211 hasConceptScore W2998905211C119056186 @default.
• W2998905211 hasConceptScore W2998905211C127561419 @default.
• W2998905211 hasConceptScore W2998905211C145059251 @default.
• W2998905211 hasConceptScore W2998905211C1491633281 @default.
• W2998905211 hasConceptScore W2998905211C173396325 @default.
• W2998905211 hasConceptScore W2998905211C190283241 @default.
• W2998905211 hasConceptScore W2998905211C29537977 @default.
• W2998905211 hasConceptScore W2998905211C502942594 @default.
• W2998905211 hasConceptScore W2998905211C54355233 @default.
• W2998905211 hasConceptScore W2998905211C62112901 @default.
• W2998905211 hasConceptScore W2998905211C81885089 @default.
• W2998905211 hasConceptScore W2998905211C86803240 @default.
• W2998905211 hasConceptScore W2998905211C95444343 @default.
• W2998905211 hasConceptScore W2998905211C97037327 @default.

• next