Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998910874> ?p ?o ?g. }
- W2998910874 endingPage "1691" @default.
- W2998910874 startingPage "1682" @default.
- W2998910874 abstract "A series of novel N′-([2-aryl-5-methyl-1,3-oxazole-4-yl]methylene)isonicotino/nicotino hydrazides 10a-l were prepared by the condensation reaction of 2-aryl-5-methyl-1,3-oxazole-4-carbaldehydes 8a-f with the corresponding isonicotino/nicotino hydrazides 9a/9b. The structures of the new compounds were elucidated by various spectroanalytical techniques, including IR, 1H NMR, 13C NMR, elemental (C,H,N), and mass analysis. All the newly prepared INH-1,3-oxazole hybrids were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. Among all the synthesized hybrids, compounds 10c and 10i derivatives displayed highest antitubercular activity with minimal inhibitory concentration 1.56 μg/mL. Further, molecular docking studies against the InhA enzyme were carried out to understand the interactions between potent hybrids and the target enzyme. Thus, these kind hybrids have the potentiality for the discovery of new antitubercular agents for deployment in the control and eradication of tuberculosis." @default.
- W2998910874 created "2020-01-23" @default.
- W2998910874 creator A5003286211 @default.
- W2998910874 creator A5067689598 @default.
- W2998910874 date "2020-04-01" @default.
- W2998910874 modified "2023-09-23" @default.
- W2998910874 title "1,3‐Oxazole‐isoniazid hybrids: Synthesis, antitubercular activity, and their docking studies" @default.
- W2998910874 cites W1763205388 @default.
- W2998910874 cites W1896929128 @default.
- W2998910874 cites W1965954804 @default.
- W2998910874 cites W1980108230 @default.
- W2998910874 cites W1981213532 @default.
- W2998910874 cites W1998235488 @default.
- W2998910874 cites W2015956861 @default.
- W2998910874 cites W2021350885 @default.
- W2998910874 cites W2026349425 @default.
- W2998910874 cites W2030920860 @default.
- W2998910874 cites W2073312276 @default.
- W2998910874 cites W2075958177 @default.
- W2998910874 cites W2076777135 @default.
- W2998910874 cites W2083655429 @default.
- W2998910874 cites W2135193909 @default.
- W2998910874 cites W2165803546 @default.
- W2998910874 cites W2205238045 @default.
- W2998910874 cites W2256742438 @default.
- W2998910874 cites W2331586236 @default.
- W2998910874 cites W2468711966 @default.
- W2998910874 cites W2507508898 @default.
- W2998910874 cites W2536177171 @default.
- W2998910874 cites W2543696967 @default.
- W2998910874 cites W2553019514 @default.
- W2998910874 cites W2571239174 @default.
- W2998910874 cites W2574564928 @default.
- W2998910874 cites W2598858367 @default.
- W2998910874 cites W2604532441 @default.
- W2998910874 cites W2738485098 @default.
- W2998910874 cites W2752822150 @default.
- W2998910874 cites W2949679907 @default.
- W2998910874 cites W2950010283 @default.
- W2998910874 cites W3022036913 @default.
- W2998910874 doi "https://doi.org/10.1002/jhet.3893" @default.
- W2998910874 hasPublicationYear "2020" @default.
- W2998910874 type Work @default.
- W2998910874 sameAs 2998910874 @default.
- W2998910874 citedByCount "16" @default.
- W2998910874 countsByYear W29989108742021 @default.
- W2998910874 countsByYear W29989108742022 @default.
- W2998910874 countsByYear W29989108742023 @default.
- W2998910874 crossrefType "journal-article" @default.
- W2998910874 hasAuthorship W2998910874A5003286211 @default.
- W2998910874 hasAuthorship W2998910874A5067689598 @default.
- W2998910874 hasConcept C103319777 @default.
- W2998910874 hasConcept C142724271 @default.
- W2998910874 hasConcept C159110408 @default.
- W2998910874 hasConcept C163111631 @default.
- W2998910874 hasConcept C178790620 @default.
- W2998910874 hasConcept C185592680 @default.
- W2998910874 hasConcept C21951064 @default.
- W2998910874 hasConcept C2776967927 @default.
- W2998910874 hasConcept C2777454769 @default.
- W2998910874 hasConcept C2777975735 @default.
- W2998910874 hasConcept C2778203186 @default.
- W2998910874 hasConcept C2780263894 @default.
- W2998910874 hasConcept C2780687663 @default.
- W2998910874 hasConcept C2781069245 @default.
- W2998910874 hasConcept C2781076698 @default.
- W2998910874 hasConcept C41685203 @default.
- W2998910874 hasConcept C71240020 @default.
- W2998910874 hasConcept C71924100 @default.
- W2998910874 hasConceptScore W2998910874C103319777 @default.
- W2998910874 hasConceptScore W2998910874C142724271 @default.
- W2998910874 hasConceptScore W2998910874C159110408 @default.
- W2998910874 hasConceptScore W2998910874C163111631 @default.
- W2998910874 hasConceptScore W2998910874C178790620 @default.
- W2998910874 hasConceptScore W2998910874C185592680 @default.
- W2998910874 hasConceptScore W2998910874C21951064 @default.
- W2998910874 hasConceptScore W2998910874C2776967927 @default.
- W2998910874 hasConceptScore W2998910874C2777454769 @default.
- W2998910874 hasConceptScore W2998910874C2777975735 @default.
- W2998910874 hasConceptScore W2998910874C2778203186 @default.
- W2998910874 hasConceptScore W2998910874C2780263894 @default.
- W2998910874 hasConceptScore W2998910874C2780687663 @default.
- W2998910874 hasConceptScore W2998910874C2781069245 @default.
- W2998910874 hasConceptScore W2998910874C2781076698 @default.
- W2998910874 hasConceptScore W2998910874C41685203 @default.
- W2998910874 hasConceptScore W2998910874C71240020 @default.
- W2998910874 hasConceptScore W2998910874C71924100 @default.
- W2998910874 hasFunder F4320320767 @default.
- W2998910874 hasIssue "4" @default.
- W2998910874 hasLocation W29989108741 @default.
- W2998910874 hasOpenAccess W2998910874 @default.
- W2998910874 hasPrimaryLocation W29989108741 @default.
- W2998910874 hasRelatedWork W2011065158 @default.
- W2998910874 hasRelatedWork W2189194707 @default.
- W2998910874 hasRelatedWork W2253325234 @default.
- W2998910874 hasRelatedWork W2950504316 @default.
- W2998910874 hasRelatedWork W2952528823 @default.
- W2998910874 hasRelatedWork W2974015324 @default.