FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998916251> ?p ?o ?g. }

• W2998916251 endingPage "1169" @default.
• W2998916251 startingPage "1164" @default.
• W2998916251 abstract "The mechanism of action of anti-thymocyte globulin (ATG) in aplastic anaemia (AA) is complex. Bone marrow (BM) CD34+ cells in AA have been shown to be more apoptotic and have a higher expression of Fas antigen (Fas-ag) than in normal donors. The aims of this study were to delineate further the mechanism for increased bone marrow progenitor cell apoptosis in AA and investigate the effects of ATG on apoptosis and Fas-ag expression. BM was obtained from six normal donors and 10 untreated AA patients. We confirmed that AA BM CD34+ cells were more apoptotic than normal donor cells (P = 0·002). Following treatment with ATG, the mean percentage reduction of apoptosis was 34% (9·2–65·9%). BM from 30 AA and 10 normal donors was then stained for CD34, Fas-ag and 7-AminoActinomycin D. The proportion of CD34+ Fas+ cells was higher in untreated AA (P = 0·0001) than in normal donors. Results also showed that the majority of CD34+ Fas+ cells were apoptotic/dead in normal donors (mean 81%) and AA (88%), indicating that Fas is involved in apoptosis of CD34+ cells. In contrast, the majority of CD34+ Fas− cells in normal donors were live (mean 91%), while two patterns emerged in untreated AA. In seven patients, the majority of cells were live, however, in the remaining eight patients, the majority of cells were apoptotic/dead, suggesting an alternative mechanism for apoptosis in addition to Fas-ag. Finally, we have shown that in vivo ATG treatment reduced the expression of Fas-ag on AA BM CD34+ cells." @default.
• W2998916251 created "2020-01-23" @default.
• W2998916251 creator A5026448936 @default.
• W2998916251 creator A5026724408 @default.
• W2998916251 creator A5041803179 @default.
• W2998916251 creator A5073611529 @default.
• W2998916251 creator A5090103959 @default.
• W2998916251 date "2000-12-01" @default.
• W2998916251 modified "2023-10-17" @default.
• W2998916251 title "Mechanisms of bone marrow progenitor cell apoptosis in aplastic anaemia and the effect of anti-thymocyte globulin: examination of the role of the Fas-Fas-L interaction" @default.
• W2998916251 cites W101289525 @default.
• W2998916251 cites W105676805 @default.
• W2998916251 cites W110134706 @default.
• W2998916251 cites W1523100198 @default.
• W2998916251 cites W1613962811 @default.
• W2998916251 cites W1836932878 @default.
• W2998916251 cites W1851142847 @default.
• W2998916251 cites W1923634318 @default.
• W2998916251 cites W1970022901 @default.
• W2998916251 cites W1974496004 @default.
• W2998916251 cites W1988062919 @default.
• W2998916251 cites W1991682037 @default.
• W2998916251 cites W2012709673 @default.
• W2998916251 cites W2017868278 @default.
• W2998916251 cites W2055482423 @default.
• W2998916251 cites W2071820768 @default.
• W2998916251 cites W2262851522 @default.
• W2998916251 cites W2296225964 @default.
• W2998916251 cites W2341016096 @default.
• W2998916251 cites W33744869 @default.
• W2998916251 doi "https://doi.org/10.1111/j.1365-2141.2000.02485.x" @default.
• W2998916251 hasPublicationYear "2000" @default.
• W2998916251 type Work @default.
• W2998916251 sameAs 2998916251 @default.
• W2998916251 citedByCount "7" @default.
• W2998916251 countsByYear W29989162512016 @default.
• W2998916251 crossrefType "journal-article" @default.
• W2998916251 hasAuthorship W2998916251A5026448936 @default.
• W2998916251 hasAuthorship W2998916251A5026724408 @default.
• W2998916251 hasAuthorship W2998916251A5041803179 @default.
• W2998916251 hasAuthorship W2998916251A5073611529 @default.
• W2998916251 hasAuthorship W2998916251A5090103959 @default.
• W2998916251 hasConcept C10205521 @default.
• W2998916251 hasConcept C109159458 @default.
• W2998916251 hasConcept C147483822 @default.
• W2998916251 hasConcept C153911025 @default.
• W2998916251 hasConcept C16685009 @default.
• W2998916251 hasConcept C167672396 @default.
• W2998916251 hasConcept C190283241 @default.
• W2998916251 hasConcept C201750760 @default.
• W2998916251 hasConcept C203014093 @default.
• W2998916251 hasConcept C2778954852 @default.
• W2998916251 hasConcept C2780007613 @default.
• W2998916251 hasConcept C2780882860 @default.
• W2998916251 hasConcept C28328180 @default.
• W2998916251 hasConcept C31573885 @default.
• W2998916251 hasConcept C55493867 @default.
• W2998916251 hasConcept C66008609 @default.
• W2998916251 hasConcept C71924100 @default.
• W2998916251 hasConcept C81358767 @default.
• W2998916251 hasConcept C86803240 @default.
• W2998916251 hasConcept C95444343 @default.
• W2998916251 hasConceptScore W2998916251C10205521 @default.
• W2998916251 hasConceptScore W2998916251C109159458 @default.
• W2998916251 hasConceptScore W2998916251C147483822 @default.
• W2998916251 hasConceptScore W2998916251C153911025 @default.
• W2998916251 hasConceptScore W2998916251C16685009 @default.
• W2998916251 hasConceptScore W2998916251C167672396 @default.
• W2998916251 hasConceptScore W2998916251C190283241 @default.
• W2998916251 hasConceptScore W2998916251C201750760 @default.
• W2998916251 hasConceptScore W2998916251C203014093 @default.
• W2998916251 hasConceptScore W2998916251C2778954852 @default.
• W2998916251 hasConceptScore W2998916251C2780007613 @default.
• W2998916251 hasConceptScore W2998916251C2780882860 @default.
• W2998916251 hasConceptScore W2998916251C28328180 @default.
• W2998916251 hasConceptScore W2998916251C31573885 @default.
• W2998916251 hasConceptScore W2998916251C55493867 @default.
• W2998916251 hasConceptScore W2998916251C66008609 @default.
• W2998916251 hasConceptScore W2998916251C71924100 @default.
• W2998916251 hasConceptScore W2998916251C81358767 @default.
• W2998916251 hasConceptScore W2998916251C86803240 @default.
• W2998916251 hasConceptScore W2998916251C95444343 @default.
• W2998916251 hasIssue "4" @default.
• W2998916251 hasLocation W29989162511 @default.
• W2998916251 hasOpenAccess W2998916251 @default.
• W2998916251 hasPrimaryLocation W29989162511 @default.
• W2998916251 hasRelatedWork W1998228373 @default.
• W2998916251 hasRelatedWork W2027927113 @default.
• W2998916251 hasRelatedWork W2054167115 @default.
• W2998916251 hasRelatedWork W2063113696 @default.
• W2998916251 hasRelatedWork W2097466377 @default.
• W2998916251 hasRelatedWork W2156396639 @default.
• W2998916251 hasRelatedWork W2322667139 @default.
• W2998916251 hasRelatedWork W2416649916 @default.
• W2998916251 hasRelatedWork W2564717365 @default.
• W2998916251 hasRelatedWork W3029982150 @default.
• W2998916251 hasVolume "111" @default.
• W2998916251 isParatext "false" @default.

• next