Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998925601> ?p ?o ?g. }
- W2998925601 abstract "Broadly neutralizing antibodies (bNAbs) can prevent a new HIV-1 infection and can at least temporarily suppress an established infection. However, antibody-resistant viruses rapidly emerge in infected persons treated with any single bNAb. Several bispecific antibodies have been developed to increase the breadth of these antibodies, but typically only one arm of these bispecific constructs binds the HIV-1 envelope glycoprotein trimer (Env). Here, we develop and characterize bispecific constructs based on well-characterized V2-glycan and V3-glycan bNAbs and show that at least one member of this class is more potent than its parental antibodies, indicating that they can simultaneously bind both of these epitopes of a single Env trimer. These data show that bispecific antibody-like proteins can achieve greater neutralization potency than the bNAbs from which they were derived." @default.
- W2998925601 created "2020-01-23" @default.
- W2998925601 creator A5003369874 @default.
- W2998925601 creator A5013937739 @default.
- W2998925601 creator A5054720102 @default.
- W2998925601 creator A5061055012 @default.
- W2998925601 creator A5080624318 @default.
- W2998925601 date "2020-02-25" @default.
- W2998925601 modified "2023-10-11" @default.
- W2998925601 title "A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies" @default.
- W2998925601 cites W1533750546 @default.
- W2998925601 cites W1568693476 @default.
- W2998925601 cites W1974431423 @default.
- W2998925601 cites W1989762371 @default.
- W2998925601 cites W1992423971 @default.
- W2998925601 cites W1994933959 @default.
- W2998925601 cites W2001483547 @default.
- W2998925601 cites W2038110764 @default.
- W2998925601 cites W2070086938 @default.
- W2998925601 cites W2073383703 @default.
- W2998925601 cites W2085577978 @default.
- W2998925601 cites W2093961711 @default.
- W2998925601 cites W2108692663 @default.
- W2998925601 cites W2113236498 @default.
- W2998925601 cites W2118274231 @default.
- W2998925601 cites W2118820599 @default.
- W2998925601 cites W2122198333 @default.
- W2998925601 cites W2126255146 @default.
- W2998925601 cites W2132783668 @default.
- W2998925601 cites W2133367683 @default.
- W2998925601 cites W2134950373 @default.
- W2998925601 cites W2135151522 @default.
- W2998925601 cites W2143019707 @default.
- W2998925601 cites W2146478787 @default.
- W2998925601 cites W2150999673 @default.
- W2998925601 cites W2153747683 @default.
- W2998925601 cites W2200798239 @default.
- W2998925601 cites W2262255609 @default.
- W2998925601 cites W2264748401 @default.
- W2998925601 cites W2294858472 @default.
- W2998925601 cites W2297185686 @default.
- W2998925601 cites W2324835369 @default.
- W2998925601 cites W2427293830 @default.
- W2998925601 cites W2469503175 @default.
- W2998925601 cites W2473595575 @default.
- W2998925601 cites W2557191642 @default.
- W2998925601 cites W2572760626 @default.
- W2998925601 cites W2577540533 @default.
- W2998925601 cites W2581575342 @default.
- W2998925601 cites W2754021327 @default.
- W2998925601 cites W2790569009 @default.
- W2998925601 cites W2804501515 @default.
- W2998925601 cites W2813574754 @default.
- W2998925601 cites W2946638940 @default.
- W2998925601 doi "https://doi.org/10.1128/mbio.03080-19" @default.
- W2998925601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6960291" @default.
- W2998925601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31937648" @default.
- W2998925601 hasPublicationYear "2020" @default.
- W2998925601 type Work @default.
- W2998925601 sameAs 2998925601 @default.
- W2998925601 citedByCount "27" @default.
- W2998925601 countsByYear W29989256012020 @default.
- W2998925601 countsByYear W29989256012021 @default.
- W2998925601 countsByYear W29989256012022 @default.
- W2998925601 countsByYear W29989256012023 @default.
- W2998925601 crossrefType "journal-article" @default.
- W2998925601 hasAuthorship W2998925601A5003369874 @default.
- W2998925601 hasAuthorship W2998925601A5013937739 @default.
- W2998925601 hasAuthorship W2998925601A5054720102 @default.
- W2998925601 hasAuthorship W2998925601A5061055012 @default.
- W2998925601 hasAuthorship W2998925601A5080624318 @default.
- W2998925601 hasBestOaLocation W29989256011 @default.
- W2998925601 hasConcept C108625454 @default.
- W2998925601 hasConcept C14086860 @default.
- W2998925601 hasConcept C153911025 @default.
- W2998925601 hasConcept C159047783 @default.
- W2998925601 hasConcept C159654299 @default.
- W2998925601 hasConcept C178790620 @default.
- W2998925601 hasConcept C185592680 @default.
- W2998925601 hasConcept C195616568 @default.
- W2998925601 hasConcept C203014093 @default.
- W2998925601 hasConcept C206212055 @default.
- W2998925601 hasConcept C2776403692 @default.
- W2998925601 hasConcept C2779546866 @default.
- W2998925601 hasConcept C3013748606 @default.
- W2998925601 hasConcept C3020495827 @default.
- W2998925601 hasConcept C542903549 @default.
- W2998925601 hasConcept C70721500 @default.
- W2998925601 hasConcept C86803240 @default.
- W2998925601 hasConcept C97380033 @default.
- W2998925601 hasConceptScore W2998925601C108625454 @default.
- W2998925601 hasConceptScore W2998925601C14086860 @default.
- W2998925601 hasConceptScore W2998925601C153911025 @default.
- W2998925601 hasConceptScore W2998925601C159047783 @default.
- W2998925601 hasConceptScore W2998925601C159654299 @default.
- W2998925601 hasConceptScore W2998925601C178790620 @default.
- W2998925601 hasConceptScore W2998925601C185592680 @default.
- W2998925601 hasConceptScore W2998925601C195616568 @default.
- W2998925601 hasConceptScore W2998925601C203014093 @default.
- W2998925601 hasConceptScore W2998925601C206212055 @default.