Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998928612> ?p ?o ?g. }
- W2998928612 endingPage "92" @default.
- W2998928612 startingPage "67" @default.
- W2998928612 abstract "Stroke is among the most common causes of adult disability worldwide, and its disease burden is shifting towards that of a long-term condition. Therefore, the development of approaches to enhance recovery and augment neural repair after stroke will be critical. Recovery after stroke involves comple x interrelated systems of neural repair. There are changes in both structure (at the molecular, cellular, and tissue levels) and function (in terms of excitability, cortical maps, and networks) that occur spontaneously within the brain. Several approaches to augment neural repair through enhancing these changes are under study. These include identifying novel drug targets, implementing rehabilitation strategies, and developing new neurotechnologies. Each of these approaches has its own array of different proposed mechanisms. Current investigation has emphasized both cellular and circuit-based targets in both gray and white matter, including axon sprouting, dendritic branching, neurogenesis, axon preservation, remyelination, blood brain barrier integrity, blockade of extracellular inhibitory signals, alteration of excitability, and promotion of new brain cortical maps and networks. Herein, we review for clinicians recovery after stroke, basic elements of spontaneous neural repair, and ongoing work to augment neural repair. Future study requires alignment of basic, translational, and clinical research. The field continues to grow while becoming more clearly defined. As thrombolysis changed stroke care in the 1990 s and thrombectomy in the 2010 s, the augmentation of neural repair and recovery after stroke may revolutionize care for these patients in the coming decade." @default.
- W2998928612 created "2020-01-23" @default.
- W2998928612 creator A5021484069 @default.
- W2998928612 creator A5029999868 @default.
- W2998928612 creator A5061474894 @default.
- W2998928612 creator A5091447153 @default.
- W2998928612 date "2020-02-11" @default.
- W2998928612 modified "2023-10-14" @default.
- W2998928612 title "Translating concepts of neural repair after stroke: Structural and functional targets for recovery" @default.
- W2998928612 cites W1481991296 @default.
- W2998928612 cites W1503485798 @default.
- W2998928612 cites W1522634666 @default.
- W2998928612 cites W1548786914 @default.
- W2998928612 cites W1566510795 @default.
- W2998928612 cites W1571518317 @default.
- W2998928612 cites W1575714392 @default.
- W2998928612 cites W1600389418 @default.
- W2998928612 cites W184818863 @default.
- W2998928612 cites W1894429194 @default.
- W2998928612 cites W1895792354 @default.
- W2998928612 cites W191572601 @default.
- W2998928612 cites W1963213812 @default.
- W2998928612 cites W1964420796 @default.
- W2998928612 cites W1966525994 @default.
- W2998928612 cites W1966869460 @default.
- W2998928612 cites W1969450508 @default.
- W2998928612 cites W1970823387 @default.
- W2998928612 cites W1971301921 @default.
- W2998928612 cites W1973619847 @default.
- W2998928612 cites W1974034780 @default.
- W2998928612 cites W1974716477 @default.
- W2998928612 cites W1974791004 @default.
- W2998928612 cites W1977213877 @default.
- W2998928612 cites W1977667876 @default.
- W2998928612 cites W1978607907 @default.
- W2998928612 cites W1978707401 @default.
- W2998928612 cites W1978936839 @default.
- W2998928612 cites W1979226561 @default.
- W2998928612 cites W1981596049 @default.
- W2998928612 cites W1981990510 @default.
- W2998928612 cites W1982850249 @default.
- W2998928612 cites W1984626876 @default.
- W2998928612 cites W1986160938 @default.
- W2998928612 cites W1989687497 @default.
- W2998928612 cites W1990400194 @default.
- W2998928612 cites W1990531942 @default.
- W2998928612 cites W1996043318 @default.
- W2998928612 cites W1998675597 @default.
- W2998928612 cites W1999409152 @default.
- W2998928612 cites W2001500938 @default.
- W2998928612 cites W2001908895 @default.
- W2998928612 cites W2002252799 @default.
- W2998928612 cites W2003674452 @default.
- W2998928612 cites W2004264059 @default.
- W2998928612 cites W2005417534 @default.
- W2998928612 cites W2006258400 @default.
- W2998928612 cites W2007313337 @default.
- W2998928612 cites W2007543609 @default.
- W2998928612 cites W2009136833 @default.
- W2998928612 cites W2009623771 @default.
- W2998928612 cites W2009757017 @default.
- W2998928612 cites W2011783556 @default.
- W2998928612 cites W2014100425 @default.
- W2998928612 cites W2015202334 @default.
- W2998928612 cites W2022518425 @default.
- W2998928612 cites W2024285156 @default.
- W2998928612 cites W2024880767 @default.
- W2998928612 cites W2027281195 @default.
- W2998928612 cites W2027784268 @default.
- W2998928612 cites W2028832381 @default.
- W2998928612 cites W2029075996 @default.
- W2998928612 cites W2030769017 @default.
- W2998928612 cites W2031809301 @default.
- W2998928612 cites W2033204490 @default.
- W2998928612 cites W2037443393 @default.
- W2998928612 cites W2038392123 @default.
- W2998928612 cites W2038995683 @default.
- W2998928612 cites W2039264305 @default.
- W2998928612 cites W2039498097 @default.
- W2998928612 cites W2040868194 @default.
- W2998928612 cites W2041318300 @default.
- W2998928612 cites W2041388197 @default.
- W2998928612 cites W2042073008 @default.
- W2998928612 cites W2043441080 @default.
- W2998928612 cites W2044443383 @default.
- W2998928612 cites W2045421141 @default.
- W2998928612 cites W2045757887 @default.
- W2998928612 cites W2046780183 @default.
- W2998928612 cites W2047216755 @default.
- W2998928612 cites W2049524944 @default.
- W2998928612 cites W2050382554 @default.
- W2998928612 cites W2051020258 @default.
- W2998928612 cites W2051423370 @default.
- W2998928612 cites W2053012673 @default.
- W2998928612 cites W2053041901 @default.
- W2998928612 cites W2053646390 @default.
- W2998928612 cites W2053646585 @default.
- W2998928612 cites W2054287847 @default.