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- W2998949952 abstract "The aim of our study was to justify substitution of dissolution analysis for NIR measurement of Toremifene 80 mg tablets. We studied implementation of a NIRS method by integrating the method development to discrimination power of the dissolution method. Hence, we analyzed 20 DoE tablet batches and studied which of the critical formulation factors affecting dissolution were statistically significant. To study if these factors can be detected by NIRS, PLS calibration models were developed. Finally, PLS model was built to correlate NIR data with the actual dissolution results to predict the released amount of toremifene in 30 min. To obtain the data the tablet batches were measured by NIR using diffuse reflectance technique and multivariate analysis tool was used to calibrate the NIRS models. Correlations between the critical formulation factors and the NIR spectra of Toremifene 80 mg tablet were shown and it was thus justified to develop a NIRS prediction model for dissolution. Variance (R2), standard error of estimate (SEE) and standard error of prediction (SEP) of the model were 90.0%, 4.3% and 5.9%, respectively. It was thus shown that multi-phased and time consuming dissolution procedure could be substituted for fast non-invasive NIRS method." @default.
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- W2998949952 date "2020-03-01" @default.
- W2998949952 modified "2023-09-26" @default.
- W2998949952 title "Prediction of drug dissolution from Toremifene 80 mg tablets by NIR spectroscopy" @default.
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- W2998949952 doi "https://doi.org/10.1016/j.ijpharm.2020.119028" @default.
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