Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998975894> ?p ?o ?g. }
- W2998975894 endingPage "1512" @default.
- W2998975894 startingPage "1496" @default.
- W2998975894 abstract "We report a detailed characterization of Eu3+ and Tb3+ complexes derived from a tripyridinophane macrocycle bearing three acetate side arms (H3tpptac). Tpptac3– displays an overall basicity (∑ log KiH) of 24.5, provides the formation of mononuclear ML species, and shows a good binding affinity for Ln3+ (log KLnL = 17.5–18.7). These complexes are also thermodynamically stable at physiological pH (pEu = 18.6, pTb = 18.0). It should be noted that the pGd value of Gd-tpptac (18.4) is only slightly lower than that of commercially available MRI contrast agents such as Gd-dota (pGd = 19.2). Moreover, a very good selectivity for these ions over the endogenous cations (log KCuL = 14.4, log KZnL = 12.9, and log KCaL = 9.3) is observed. The X-ray structure of the terbium complex shows the metal coordinated by the nine N6O3 donor set of the ligand and one inner-sphere water molecule. DFT calculations result in two Eu-tpptac structures with similar bond energies (ΔE = 0.145 eV): one structure in which the water is coordinated to the metal ion and one structure in which the water molecule is farther away from the ion, bound to the ligand with an OH−π bond. By detailed luminescence experiments, we demonstrate that the europium complex in aqueous solution presents a hydration equilibrium between nine-coordinate, dehydrated [Eu-tpptac]0 and ten-coordinate, monohydrated [Eu-tpptac(H2O)]0 species. A similar trend is observed for the terbium complex. Despite the presence of this hydration equilibrium, the H3tpptac ligand sensitizes Eu3+ and Tb3+ luminescence efficiently in buffered water at physiological pH. Particularly, the terbium complex displays a long excited-state lifetime of 2.24 ms and an overall quantum yield of 33% with a brightness of 3600 M–1 cm–1. Such features of Ln3+ complexes of H3tpptac indicate that this platform appears to be particularly appealing for the further development of luminescent lanthanide labels." @default.
- W2998975894 created "2020-01-23" @default.
- W2998975894 creator A5002165583 @default.
- W2998975894 creator A5002776907 @default.
- W2998975894 creator A5007742140 @default.
- W2998975894 creator A5013811421 @default.
- W2998975894 creator A5045804285 @default.
- W2998975894 creator A5048373929 @default.
- W2998975894 creator A5049779217 @default.
- W2998975894 creator A5053220484 @default.
- W2998975894 creator A5056789357 @default.
- W2998975894 creator A5059739403 @default.
- W2998975894 date "2020-01-08" @default.
- W2998975894 modified "2023-10-18" @default.
- W2998975894 title "Tripyridinophane Platform Containing Three Acetate Pendant Arms: An Attractive Structural Entry for the Development of Neutral Eu(III) and Tb(III) Complexes in Aqueous Solution" @default.
- W2998975894 cites W1805972161 @default.
- W2998975894 cites W1969137131 @default.
- W2998975894 cites W1969779901 @default.
- W2998975894 cites W1975901175 @default.
- W2998975894 cites W1975966943 @default.
- W2998975894 cites W1976075691 @default.
- W2998975894 cites W1982249699 @default.
- W2998975894 cites W1988256833 @default.
- W2998975894 cites W1992178675 @default.
- W2998975894 cites W1992950966 @default.
- W2998975894 cites W1997079896 @default.
- W2998975894 cites W1999965419 @default.
- W2998975894 cites W2000093402 @default.
- W2998975894 cites W2004441028 @default.
- W2998975894 cites W2005292788 @default.
- W2998975894 cites W2006519199 @default.
- W2998975894 cites W2013759064 @default.
- W2998975894 cites W2015501698 @default.
- W2998975894 cites W2015539116 @default.
- W2998975894 cites W2016890925 @default.
- W2998975894 cites W2017149819 @default.
- W2998975894 cites W2018625335 @default.
- W2998975894 cites W2019240520 @default.
- W2998975894 cites W2021137787 @default.
- W2998975894 cites W2025369658 @default.
- W2998975894 cites W2038664151 @default.
- W2998975894 cites W2039784728 @default.
- W2998975894 cites W2041417902 @default.
- W2998975894 cites W2043022830 @default.
- W2998975894 cites W2045525229 @default.
- W2998975894 cites W2050936234 @default.
- W2998975894 cites W2058101704 @default.
- W2998975894 cites W2058236594 @default.
- W2998975894 cites W2059135111 @default.
- W2998975894 cites W2059362618 @default.
- W2998975894 cites W2060565229 @default.
- W2998975894 cites W2063095710 @default.
- W2998975894 cites W2070104862 @default.
- W2998975894 cites W2071184800 @default.
- W2998975894 cites W2071448244 @default.
- W2998975894 cites W2075106662 @default.
- W2998975894 cites W2075245509 @default.
- W2998975894 cites W2075354648 @default.
- W2998975894 cites W2087762156 @default.
- W2998975894 cites W2094922595 @default.
- W2998975894 cites W2108446403 @default.
- W2998975894 cites W2109207791 @default.
- W2998975894 cites W2114062877 @default.
- W2998975894 cites W2120022923 @default.
- W2998975894 cites W2131350133 @default.
- W2998975894 cites W2132454074 @default.
- W2998975894 cites W2132629607 @default.
- W2998975894 cites W2133290447 @default.
- W2998975894 cites W2134180542 @default.
- W2998975894 cites W2138520198 @default.
- W2998975894 cites W2140503533 @default.
- W2998975894 cites W2148686950 @default.
- W2998975894 cites W2150345533 @default.
- W2998975894 cites W2151324716 @default.
- W2998975894 cites W2151859760 @default.
- W2998975894 cites W2155269946 @default.
- W2998975894 cites W2157299367 @default.
- W2998975894 cites W2169235750 @default.
- W2998975894 cites W2171219272 @default.
- W2998975894 cites W2262208285 @default.
- W2998975894 cites W2295562476 @default.
- W2998975894 cites W2317247825 @default.
- W2998975894 cites W2326411711 @default.
- W2998975894 cites W2328144367 @default.
- W2998975894 cites W2330683408 @default.
- W2998975894 cites W2513751261 @default.
- W2998975894 cites W2524190914 @default.
- W2998975894 cites W2605199119 @default.
- W2998975894 cites W2611863351 @default.
- W2998975894 cites W2613773591 @default.
- W2998975894 cites W2731944459 @default.
- W2998975894 cites W2739000795 @default.
- W2998975894 cites W2765429407 @default.
- W2998975894 cites W2775015912 @default.
- W2998975894 cites W2786633572 @default.
- W2998975894 cites W2793010677 @default.
- W2998975894 cites W2799686016 @default.
- W2998975894 cites W2800280125 @default.