Matches in SemOpenAlex for { <https://semopenalex.org/work/W2998977471> ?p ?o ?g. }
- W2998977471 abstract "Abstract For the fluorescence imaging of biologically active small compounds, the development of compact fluorophores that do not perturb bioactivity is required. Here we report a compact derivative of fluorescent 1,3a,6a-triazapentalenes, 2-isobutenylcarbonyl-1,3a,6a-triazapentalene (TAP-VK1), as a fluorescent labeling reagent. The reaction of TAP-VK1 with various aliphatic thiols proceeds smoothly to afford the corresponding 1,4-adducts in high yields, and nucleophiles other than thiols do not react. After the addition of thiol groups in dichloromethane, the emission maximum of TAP-VK1 shifts to a shorter wavelength and the fluorescence intensity is substantially increased. The utility of TAP-VK1 as a compact fluorescent labeling reagent is clearly demonstrated by the labeling of Captopril, which is a small molecular drug for hypertension. The successful imaging of Captopril, one of the most compact drugs, in this study demonstrates the usefulness of compact fluorophores for mechanistic studies." @default.
- W2998977471 created "2020-01-23" @default.
- W2998977471 creator A5003273132 @default.
- W2998977471 creator A5011046792 @default.
- W2998977471 creator A5027842743 @default.
- W2998977471 creator A5058240973 @default.
- W2998977471 creator A5072198320 @default.
- W2998977471 creator A5073909129 @default.
- W2998977471 creator A5076818771 @default.
- W2998977471 creator A5081569662 @default.
- W2998977471 creator A5083483534 @default.
- W2998977471 creator A5088196971 @default.
- W2998977471 date "2020-01-09" @default.
- W2998977471 modified "2023-10-16" @default.
- W2998977471 title "Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent" @default.
- W2998977471 cites W1579899042 @default.
- W2998977471 cites W1818705748 @default.
- W2998977471 cites W1904255855 @default.
- W2998977471 cites W1966197160 @default.
- W2998977471 cites W1967094458 @default.
- W2998977471 cites W1967257356 @default.
- W2998977471 cites W1972839457 @default.
- W2998977471 cites W1973238993 @default.
- W2998977471 cites W1979210862 @default.
- W2998977471 cites W2000314850 @default.
- W2998977471 cites W2020763460 @default.
- W2998977471 cites W2031139496 @default.
- W2998977471 cites W2042624724 @default.
- W2998977471 cites W2043476797 @default.
- W2998977471 cites W2066778206 @default.
- W2998977471 cites W2067763402 @default.
- W2998977471 cites W2084147631 @default.
- W2998977471 cites W2084636686 @default.
- W2998977471 cites W2100480866 @default.
- W2998977471 cites W2102308519 @default.
- W2998977471 cites W2112850441 @default.
- W2998977471 cites W2123942875 @default.
- W2998977471 cites W2137383411 @default.
- W2998977471 cites W2146399721 @default.
- W2998977471 cites W2156674416 @default.
- W2998977471 cites W2169669031 @default.
- W2998977471 cites W2276564552 @default.
- W2998977471 cites W2316083346 @default.
- W2998977471 cites W2328224778 @default.
- W2998977471 cites W2330132564 @default.
- W2998977471 cites W2335534965 @default.
- W2998977471 cites W2467099313 @default.
- W2998977471 cites W2486604872 @default.
- W2998977471 cites W2488141058 @default.
- W2998977471 cites W2538375405 @default.
- W2998977471 cites W2560052970 @default.
- W2998977471 cites W2565218220 @default.
- W2998977471 cites W2585314674 @default.
- W2998977471 cites W2588093328 @default.
- W2998977471 cites W2604433308 @default.
- W2998977471 cites W2897074581 @default.
- W2998977471 cites W2949250060 @default.
- W2998977471 doi "https://doi.org/10.1038/s42004-019-0250-0" @default.
- W2998977471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36703318" @default.
- W2998977471 hasPublicationYear "2020" @default.
- W2998977471 type Work @default.
- W2998977471 sameAs 2998977471 @default.
- W2998977471 citedByCount "12" @default.
- W2998977471 countsByYear W29989774712020 @default.
- W2998977471 countsByYear W29989774712021 @default.
- W2998977471 countsByYear W29989774712022 @default.
- W2998977471 countsByYear W29989774712023 @default.
- W2998977471 crossrefType "journal-article" @default.
- W2998977471 hasAuthorship W2998977471A5003273132 @default.
- W2998977471 hasAuthorship W2998977471A5011046792 @default.
- W2998977471 hasAuthorship W2998977471A5027842743 @default.
- W2998977471 hasAuthorship W2998977471A5058240973 @default.
- W2998977471 hasAuthorship W2998977471A5072198320 @default.
- W2998977471 hasAuthorship W2998977471A5073909129 @default.
- W2998977471 hasAuthorship W2998977471A5076818771 @default.
- W2998977471 hasAuthorship W2998977471A5081569662 @default.
- W2998977471 hasAuthorship W2998977471A5083483534 @default.
- W2998977471 hasAuthorship W2998977471A5088196971 @default.
- W2998977471 hasBestOaLocation W29989774711 @default.
- W2998977471 hasConcept C106159729 @default.
- W2998977471 hasConcept C108204754 @default.
- W2998977471 hasConcept C111771559 @default.
- W2998977471 hasConcept C120665830 @default.
- W2998977471 hasConcept C121332964 @default.
- W2998977471 hasConcept C127413603 @default.
- W2998977471 hasConcept C161790260 @default.
- W2998977471 hasConcept C162324750 @default.
- W2998977471 hasConcept C17538187 @default.
- W2998977471 hasConcept C178790620 @default.
- W2998977471 hasConcept C178907741 @default.
- W2998977471 hasConcept C185592680 @default.
- W2998977471 hasConcept C21951064 @default.
- W2998977471 hasConcept C2780400988 @default.
- W2998977471 hasConcept C2780471494 @default.
- W2998977471 hasConcept C2781324293 @default.
- W2998977471 hasConcept C40875361 @default.
- W2998977471 hasConcept C75473681 @default.
- W2998977471 hasConcept C87717796 @default.
- W2998977471 hasConcept C91881484 @default.
- W2998977471 hasConceptScore W2998977471C106159729 @default.