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• W2998986799 abstract "PD-1 checkpoint blockage with an antibody has been shown to reduce amyloid-β plaques, associated pathologies and cognitive impairment in mouse models. More recently, this approach has shown effectiveness in a tauopathy mouse model to improve cognition and reduce tau lesions. Follow-up studies by other laboratories did not see similar benefits of this type of therapy in other amyloid-β plaque models. Here, we report a modest increase in locomotor activity but no effect on cognition or tau pathology,,lack of efficacy in a different more commonly used tauopathy model, following a weekly treatment for 12 weeks with the same PD-1 antibody and isotype control as in the original Aβ- and tau-targeting studies. These findings indicate that further research is needed before clinical trials based on PD-1 checkpoint immune blockage are devised for tauopathies." @default.
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• W2998986799 date "2020-01-14" @default.
• W2998986799 modified "2023-10-18" @default.
• W2998986799 title "Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model" @default.
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• W2998986799 doi "https://doi.org/10.3389/fnagi.2019.00377" @default.
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