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• W2998993043 startingPage "207" @default.
• W2998993043 abstract "Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of disrupting genome function, inducing genome instability and mutation. Such risks are due to primary oxidative DNA damage and also mediated by the repair process. This leads to a delicate decision process for the cell as to whether to repair a damaged base at a specific genomic location or better leave it unrepaired. Persistent DNA damage can disrupt genome function, but on the other hand it can also contribute to gene regulation by serving as an epigenetic mark. When such processes are out of balance, pathophysiological conditions could get accelerated, because oxidative DNA damage and resulting mutagenic processes are tightly linked to ageing, inflammation, and the development of multiple age-related diseases, such as cancer and neurodegenerative disorders. Recent technological advancements and novel data analysis strategies have revealed that oxidative DNA damage, its repair, and related mutations distribute heterogeneously over the genome at multiple levels of resolution. The involved mechanisms act in the context of genome sequence, in interaction with genome function and chromatin. This review addresses what we currently know about the genome distribution of oxidative DNA damage, repair intermediates, and mutations. It will specifically focus on the various methodologies to measure oxidative DNA damage distribution and discuss the mechanistic conclusions derived from the different approaches. It will also address the consequences of oxidative DNA damage, specifically how it gives rise to mutations, genome instability, and how it can act as an epigenetic mark." @default.
• W2998993043 created "2020-01-23" @default.
• W2998993043 creator A5029443962 @default.
• W2998993043 date "2020-01-01" @default.
• W2998993043 modified "2023-10-16" @default.
• W2998993043 title "The genomics of oxidative DNA damage, repair, and resulting mutagenesis" @default.
• W2998993043 cites W1487243507 @default.
• W2998993043 cites W1563750692 @default.
• W2998993043 cites W1910096403 @default.
• W2998993043 cites W1965151932 @default.
• W2998993043 cites W1966708146 @default.
• W2998993043 cites W1972516382 @default.
• W2998993043 cites W1973997983 @default.
• W2998993043 cites W1978189157 @default.
• W2998993043 cites W1978236080 @default.
• W2998993043 cites W1978953588 @default.
• W2998993043 cites W1980011868 @default.
• W2998993043 cites W1980190480 @default.
• W2998993043 cites W1981565987 @default.
• W2998993043 cites W1981721049 @default.
• W2998993043 cites W1981927194 @default.
• W2998993043 cites W1983660137 @default.
• W2998993043 cites W1983825041 @default.
• W2998993043 cites W1984483867 @default.
• W2998993043 cites W1985215725 @default.
• W2998993043 cites W1989456683 @default.
• W2998993043 cites W1990495935 @default.
• W2998993043 cites W1990515364 @default.
• W2998993043 cites W1992241785 @default.
• W2998993043 cites W1992478928 @default.
• W2998993043 cites W1995304831 @default.
• W2998993043 cites W1998028181 @default.
• W2998993043 cites W1999872096 @default.
• W2998993043 cites W2005088616 @default.
• W2998993043 cites W2011804819 @default.
• W2998993043 cites W2013499563 @default.
• W2998993043 cites W2015773125 @default.
• W2998993043 cites W2021142376 @default.
• W2998993043 cites W2022414823 @default.
• W2998993043 cites W2027364965 @default.
• W2998993043 cites W2033172828 @default.
• W2998993043 cites W2035144476 @default.
• W2998993043 cites W2036685293 @default.
• W2998993043 cites W2042793731 @default.
• W2998993043 cites W2043021911 @default.
• W2998993043 cites W2045899523 @default.
• W2998993043 cites W2052760813 @default.
• W2998993043 cites W2055231165 @default.
• W2998993043 cites W2060553286 @default.
• W2998993043 cites W2062578223 @default.
• W2998993043 cites W2065107886 @default.
• W2998993043 cites W2066261076 @default.
• W2998993043 cites W2066686326 @default.
• W2998993043 cites W2067117301 @default.
• W2998993043 cites W2067393096 @default.
• W2998993043 cites W2068533511 @default.
• W2998993043 cites W2068668716 @default.
• W2998993043 cites W2069902477 @default.
• W2998993043 cites W2072063319 @default.
• W2998993043 cites W2074018558 @default.
• W2998993043 cites W2074120812 @default.
• W2998993043 cites W2076316122 @default.
• W2998993043 cites W2076539445 @default.
• W2998993043 cites W2077751281 @default.
• W2998993043 cites W2079555232 @default.
• W2998993043 cites W2084695608 @default.
• W2998993043 cites W2087290238 @default.
• W2998993043 cites W2089126898 @default.
• W2998993043 cites W2089309776 @default.
• W2998993043 cites W2089959863 @default.
• W2998993043 cites W2092864864 @default.
• W2998993043 cites W2093106495 @default.
• W2998993043 cites W2094156327 @default.
• W2998993043 cites W2095301528 @default.
• W2998993043 cites W2097706483 @default.
• W2998993043 cites W2100750898 @default.
• W2998993043 cites W2100904609 @default.
• W2998993043 cites W2102083376 @default.
• W2998993043 cites W2107332686 @default.
• W2998993043 cites W2107356675 @default.
• W2998993043 cites W2107988671 @default.
• W2998993043 cites W2112001893 @default.
• W2998993043 cites W2114023704 @default.
• W2998993043 cites W2114146570 @default.
• W2998993043 cites W2114809075 @default.
• W2998993043 cites W2116094026 @default.
• W2998993043 cites W2116737251 @default.
• W2998993043 cites W2119775467 @default.
• W2998993043 cites W2121906867 @default.
• W2998993043 cites W2125038006 @default.
• W2998993043 cites W2127604631 @default.
• W2998993043 cites W2128036243 @default.
• W2998993043 cites W2128473487 @default.
• W2998993043 cites W2128528820 @default.
• W2998993043 cites W2129136620 @default.
• W2998993043 cites W2129540903 @default.
• W2998993043 cites W2134259738 @default.
• W2998993043 cites W2134390575 @default.

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