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- W2998994120 abstract "Abstract The emergence of drug-resistant influenza type A viruses (IAVs) necessitates the development of novel anti-IAV agents. Here, we target the IAV hemagglutinin (HA) protein using multivalent peptide library screens and identify PVF-tet, a peptide-based HA inhibitor. PVF-tet inhibits IAV cytopathicity and propagation in cells by binding to newly synthesized HA, rather than to the HA of the parental virus, thus inducing the accumulation of HA within a unique structure, the inducible amphisome, whose production from the autophagosome is accelerated by PVF-tet. The amphisome is also produced in response to IAV infection in the absence of PVF-tet by cells overexpressing ABC transporter subfamily A3, which plays an essential role in the maturation of multivesicular endosomes into the lamellar body, a lipid-sorting organelle. Our results show that the inducible amphisomes can function as a type of organelle-based anti-viral machinery by sequestering HA. PVF-tet efficiently rescues mice from the lethality of IAV infection." @default.
- W2998994120 created "2020-01-23" @default.
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- W2998994120 date "2020-01-09" @default.
- W2998994120 modified "2023-10-15" @default.
- W2998994120 title "The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection" @default.
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- W2998994120 doi "https://doi.org/10.1038/s41467-019-13974-w" @default.
- W2998994120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6952414" @default.
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