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- W2998994639 abstract "Costs may hinder the implementation of BK polyomavirus (BKV)-DNAemia screening in resource-limited kidney transplant (KT) centers. We analyzed data from two studies to assess the performance and potential cost saving of a dual-step screening strategy based on the use of a preliminary qualitative semi-nested PCR (snPCR) assay followed by BKV-DNAemia quantification after KT. In the preliminary study, in which 130 samples from 33 KT recipients were screened for BKV-DNAemia, the estimated positive and negative predictive values of snPCR, as compared to quantitative PCR (qPCR), were 88% and 99%, respectively. In the second study, which included 84 KT recipients, BKV-DNAemia was detected by snPCR in 28/472 (5.9%) samples and confirmed by qPCR in 26 samples of 21 (25%) subjects. No graft loss occurred among KT recipients who developed BKV-DNAemia. Cost analyses suggested that this strategy might be a cost saving alternative for BKV-DNAemia screening for some resource-limited settings." @default.
- W2998994639 created "2020-01-23" @default.
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- W2998994639 date "2020-04-01" @default.
- W2998994639 modified "2023-10-18" @default.
- W2998994639 title "Screening for BKV-DNAEMIA after renal transplantation in a resource limited setting" @default.
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- W2998994639 doi "https://doi.org/10.1016/j.diagmicrobio.2019.114979" @default.
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