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- W2999012956 abstract "A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m 6 A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m 6 A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. Science , this issue p. 580" @default.
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- W2999012956 date "2020-01-31" @default.
- W2999012956 modified "2023-10-05" @default.
- W2999012956 title "<i>N</i> <sup>6</sup> -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription" @default.
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- W2999012956 doi "https://doi.org/10.1126/science.aay6018" @default.
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