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• W2999014918 abstract "Modern clearing techniques enable high resolution visualization and 3D reconstruction of cell populations and their structural details throughout large biological samples, including intact organs and even entire organisms. In the past decade, these methods have become more tractable and are now being utilized to provide unforeseen insights into the complexities of the nervous system. While several iterations of optical clearing techniques have been developed, some are more suitable for specific applications than others depending on the type of specimen under study. Here we review findings from select studies utilizing clearing methods to visualize the developing, injured, and diseased nervous system within numerous model systems and species. We note trends and imbalances in the types of research questions being addressed with clearing methods across these fields in neuroscience. In addition, we discuss restrictions in applying optical clearing methods for postmortem tissue from humans and large animals and emphasize the lack in continuity between studies of these species. We aim for this review to serve as a key outline of available tissue clearing methods used successfully to address issues across neuronal development, injury/repair, and aging/disease." @default.
• W2999014918 created "2020-01-23" @default.
• W2999014918 creator A5042360191 @default.
• W2999014918 creator A5087703926 @default.
• W2999014918 date "2020-03-01" @default.
• W2999014918 modified "2023-09-24" @default.
• W2999014918 title "Clearing techniques for visualizing the nervous system in development, injury, and disease" @default.
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