FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999016846> ?p ?o ?g. }

• W2999016846 endingPage "4" @default.
• W2999016846 startingPage "4" @default.
• W2999016846 abstract "In a previously published report we detailed an in situ method to quantify cell death in the renal cortex by perfusing the cell membrane impermeable fluorochrome, ethidium homodimer in situ. The objective of the present study was to use this in situ viability assay to examine cell death following the administration of nephrotoxic drugs known to produce cell death and/or injury in specific segments of the nephron. Male Sprague/Dawley rats were treated with the following nephrotoxicants: Gentamicin, amphotericin-B, and indomethacin. Results of the in situ viability assay indicated that gentamicin and amphotericin-B treatment caused cell death localized in the kidney cortex and medulla, respectively. The urinary biomarker kidney injury molecule—1 (Kim-1) showed significant increases in both gentamicin (20 fold increase) and amphotericin-B-treated (9.2 fold increase) animals. Urinary alpha glutathione-S-transferase (GST) showed significant increases for gentamicin (6.2 fold increase) only and mu GST for amphotericin-B-treated (19.1 fold increase) animals only. These results show that this in situ viability assay provides a sensitive method to identify cell death in different regions of the kidney. Furthermore, urinary alpha GST and mu GST are specific for proximal and distal tubule injury, respectively; urinary Kim-1 demonstrated greater sensitivity to both proximal and distal tubule injury." @default.
• W2999016846 created "2020-01-23" @default.
• W2999016846 creator A5014753978 @default.
• W2999016846 creator A5017642428 @default.
• W2999016846 creator A5070757560 @default.
• W2999016846 creator A5076607985 @default.
• W2999016846 creator A5081204981 @default.
• W2999016846 date "2020-01-20" @default.
• W2999016846 modified "2023-10-14" @default.
• W2999016846 title "A Method for the Evaluation of Site-Specific Nephrotoxic Injury in the Intact Rat Kidney" @default.
• W2999016846 cites W1711089154 @default.
• W2999016846 cites W1835009115 @default.
• W2999016846 cites W1913396309 @default.
• W2999016846 cites W1997042641 @default.
• W2999016846 cites W2004445783 @default.
• W2999016846 cites W2044736921 @default.
• W2999016846 cites W2047937904 @default.
• W2999016846 cites W2050703007 @default.
• W2999016846 cites W2052235099 @default.
• W2999016846 cites W2067479751 @default.
• W2999016846 cites W2069722312 @default.
• W2999016846 cites W2128169890 @default.
• W2999016846 cites W2149687213 @default.
• W2999016846 cites W2565205631 @default.
• W2999016846 cites W2604803316 @default.
• W2999016846 cites W2772818377 @default.
• W2999016846 cites W2791017812 @default.
• W2999016846 doi "https://doi.org/10.3390/toxics8010004" @default.
• W2999016846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7151727" @default.
• W2999016846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31968633" @default.
• W2999016846 hasPublicationYear "2020" @default.
• W2999016846 type Work @default.
• W2999016846 sameAs 2999016846 @default.
• W2999016846 citedByCount "2" @default.
• W2999016846 countsByYear W29990168462022 @default.
• W2999016846 countsByYear W29990168462023 @default.
• W2999016846 crossrefType "journal-article" @default.
• W2999016846 hasAuthorship W2999016846A5014753978 @default.
• W2999016846 hasAuthorship W2999016846A5017642428 @default.
• W2999016846 hasAuthorship W2999016846A5070757560 @default.
• W2999016846 hasAuthorship W2999016846A5076607985 @default.
• W2999016846 hasAuthorship W2999016846A5081204981 @default.
• W2999016846 hasBestOaLocation W29990168461 @default.
• W2999016846 hasConcept C126189478 @default.
• W2999016846 hasConcept C126322002 @default.
• W2999016846 hasConcept C1491633281 @default.
• W2999016846 hasConcept C185592680 @default.
• W2999016846 hasConcept C190283241 @default.
• W2999016846 hasConcept C2775832221 @default.
• W2999016846 hasConcept C2778577996 @default.
• W2999016846 hasConcept C2780091579 @default.
• W2999016846 hasConcept C2780472472 @default.
• W2999016846 hasConcept C2781231759 @default.
• W2999016846 hasConcept C31573885 @default.
• W2999016846 hasConcept C501593827 @default.
• W2999016846 hasConcept C53227056 @default.
• W2999016846 hasConcept C55493867 @default.
• W2999016846 hasConcept C71924100 @default.
• W2999016846 hasConcept C77411442 @default.
• W2999016846 hasConcept C98274493 @default.
• W2999016846 hasConceptScore W2999016846C126189478 @default.
• W2999016846 hasConceptScore W2999016846C126322002 @default.
• W2999016846 hasConceptScore W2999016846C1491633281 @default.
• W2999016846 hasConceptScore W2999016846C185592680 @default.
• W2999016846 hasConceptScore W2999016846C190283241 @default.
• W2999016846 hasConceptScore W2999016846C2775832221 @default.
• W2999016846 hasConceptScore W2999016846C2778577996 @default.
• W2999016846 hasConceptScore W2999016846C2780091579 @default.
• W2999016846 hasConceptScore W2999016846C2780472472 @default.
• W2999016846 hasConceptScore W2999016846C2781231759 @default.
• W2999016846 hasConceptScore W2999016846C31573885 @default.
• W2999016846 hasConceptScore W2999016846C501593827 @default.
• W2999016846 hasConceptScore W2999016846C53227056 @default.
• W2999016846 hasConceptScore W2999016846C55493867 @default.
• W2999016846 hasConceptScore W2999016846C71924100 @default.
• W2999016846 hasConceptScore W2999016846C77411442 @default.
• W2999016846 hasConceptScore W2999016846C98274493 @default.
• W2999016846 hasIssue "1" @default.
• W2999016846 hasLocation W29990168461 @default.
• W2999016846 hasLocation W29990168462 @default.
• W2999016846 hasLocation W29990168463 @default.
• W2999016846 hasLocation W29990168464 @default.
• W2999016846 hasOpenAccess W2999016846 @default.
• W2999016846 hasPrimaryLocation W29990168461 @default.
• W2999016846 hasRelatedWork W1555526809 @default.
• W2999016846 hasRelatedWork W1969805210 @default.
• W2999016846 hasRelatedWork W2031743500 @default.
• W2999016846 hasRelatedWork W2115177369 @default.
• W2999016846 hasRelatedWork W2117958464 @default.
• W2999016846 hasRelatedWork W2154406502 @default.
• W2999016846 hasRelatedWork W2473383702 @default.
• W2999016846 hasRelatedWork W2555652234 @default.
• W2999016846 hasRelatedWork W3118834953 @default.
• W2999016846 hasRelatedWork W4307262315 @default.
• W2999016846 hasVolume "8" @default.
• W2999016846 isParatext "false" @default.
• W2999016846 isRetracted "false" @default.
• W2999016846 magId "2999016846" @default.

• next