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- W2999032278 abstract "Candida albicans is a fungal pathogen and a significant cause of morbidity and mortality, particularly in people with defects, sometimes minor ones, in innate immunity. The phagocytes of the innate immune system, particularly macrophages and neutrophils, generally restrict this organism to its normal commensal niches, but C. albicans shows a robust and multifaceted response to these cell types. Inside macrophages, a key component of this response is the activation of multiple pathways for the utilization of alternative carbon sources, particularly amino acids, carboxylic acids, and N -acetylglucosamine. These carbon sources are key sources of energy and biomass but also independently promote stress resistance, induce cell wall alterations, and affect C. albicans interactions with macrophages. Engineered strains incapable of utilizing these alternative carbon pathways are attenuated in infection models. These data suggest that C. albicans recognizes nutrient composition as an indicator of specific host environments and tailors its responses accordingly." @default.
- W2999032278 created "2020-01-23" @default.
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- W2999032278 date "2020-02-25" @default.
- W2999032278 modified "2023-10-17" @default.
- W2999032278 title "Multiple Alternative Carbon Pathways Combine To Promote Candida albicans Stress Resistance, Immune Interactions, and Virulence" @default.
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- W2999032278 cites W1980561427 @default.
- W2999032278 cites W1988488847 @default.
- W2999032278 cites W1991037453 @default.
- W2999032278 cites W1993727333 @default.
- W2999032278 cites W1997290272 @default.
- W2999032278 cites W2002047195 @default.
- W2999032278 cites W2006559495 @default.
- W2999032278 cites W2017784916 @default.
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- W2999032278 cites W2032691398 @default.
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- W2999032278 doi "https://doi.org/10.1128/mbio.03070-19" @default.
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