Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999046935> ?p ?o ?g. }
- W2999046935 abstract "Abstract Chronic kidney disease (CKD) is characterized by loss of renal function and a consequent increase of serum uremic toxins, which contribute to inflammation status. Deficiency of 25-vitamin D, often found in patients with CKD, has been included as an inflammatory factor since it might modulate the immune system. The aim of this study was to investigate the role of 25-vitamin D on inflammatory pathways in healthy and uremic environment. Toll-like receptor 4 (TLR4), oxidative stress (ROS), vitamin D receptor (VDR), 1-α hydroxylase (CYP27), 24 hydroxylase, cathelicidin, and MCP-1 were evaluated in monocytes exposed to a uremic serum pool compared with healthy pool. The human monocytes lineage (U937) was incubated with or without 25-vitamin D (50 ng/ml for 24 hours). TRL4, VDR, CYP27, CYP24, and ROS were evaluated by flow cytometry. We used ELISA to measure IL-6, TNF-α, IL-10, cathelicidin, and MCP-1 in the cell culture supernatant. We observed a higher expression of TRL-4, IL-6, TNF-α, IL-10, cathelicidin and MCP-1 in monocytes incubated with uremic serum when compared with serum from healthy individuals. Supplementation of 25-vitamin D was able to reduce the expression of TRL4, cathelicidin, and MCP-1 in the uremic environment. There was no difference in the expression of VDR, CYP27 and CYP24 intracellular enzymes. This in vitro study showed that the uremic pool activates inflammatory response in monocytes, which was reversed by 25-vitamin D supplementation; this finding suggests that 25-vitamin D has an anti-inflammatory role in the uremic environment." @default.
- W2999046935 created "2020-01-23" @default.
- W2999046935 creator A5001539255 @default.
- W2999046935 creator A5009932201 @default.
- W2999046935 creator A5039338307 @default.
- W2999046935 creator A5041745890 @default.
- W2999046935 creator A5042184741 @default.
- W2999046935 creator A5065544431 @default.
- W2999046935 creator A5067676932 @default.
- W2999046935 creator A5080190120 @default.
- W2999046935 date "2020-01-10" @default.
- W2999046935 modified "2023-10-16" @default.
- W2999046935 title "25-vitamin D reduces inflammation in uremic environment" @default.
- W2999046935 cites W1608396957 @default.
- W2999046935 cites W1976452827 @default.
- W2999046935 cites W1988738875 @default.
- W2999046935 cites W2001391535 @default.
- W2999046935 cites W2003575314 @default.
- W2999046935 cites W2004465286 @default.
- W2999046935 cites W2018665788 @default.
- W2999046935 cites W2024803597 @default.
- W2999046935 cites W2036402516 @default.
- W2999046935 cites W2037975131 @default.
- W2999046935 cites W2040137092 @default.
- W2999046935 cites W2067338751 @default.
- W2999046935 cites W2075444377 @default.
- W2999046935 cites W2081121306 @default.
- W2999046935 cites W2084363831 @default.
- W2999046935 cites W2084503833 @default.
- W2999046935 cites W2084954530 @default.
- W2999046935 cites W2116558722 @default.
- W2999046935 cites W2120376107 @default.
- W2999046935 cites W2124070987 @default.
- W2999046935 cites W2124580054 @default.
- W2999046935 cites W2130454420 @default.
- W2999046935 cites W2145632027 @default.
- W2999046935 cites W2147397196 @default.
- W2999046935 cites W2157243060 @default.
- W2999046935 cites W2177493335 @default.
- W2999046935 cites W2344201375 @default.
- W2999046935 cites W2531475132 @default.
- W2999046935 cites W2532417249 @default.
- W2999046935 cites W2568133249 @default.
- W2999046935 cites W2581302565 @default.
- W2999046935 cites W2616730536 @default.
- W2999046935 cites W2621289109 @default.
- W2999046935 cites W2726505574 @default.
- W2999046935 cites W2751238393 @default.
- W2999046935 cites W2766232072 @default.
- W2999046935 cites W2769927853 @default.
- W2999046935 cites W2770434806 @default.
- W2999046935 cites W2791372685 @default.
- W2999046935 cites W2794246608 @default.
- W2999046935 cites W2884274719 @default.
- W2999046935 cites W2892633805 @default.
- W2999046935 cites W2902866635 @default.
- W2999046935 doi "https://doi.org/10.1038/s41598-019-56874-1" @default.
- W2999046935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6954254" @default.
- W2999046935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31924826" @default.
- W2999046935 hasPublicationYear "2020" @default.
- W2999046935 type Work @default.
- W2999046935 sameAs 2999046935 @default.
- W2999046935 citedByCount "11" @default.
- W2999046935 countsByYear W29990469352020 @default.
- W2999046935 countsByYear W29990469352021 @default.
- W2999046935 countsByYear W29990469352022 @default.
- W2999046935 countsByYear W29990469352023 @default.
- W2999046935 crossrefType "journal-article" @default.
- W2999046935 hasAuthorship W2999046935A5001539255 @default.
- W2999046935 hasAuthorship W2999046935A5009932201 @default.
- W2999046935 hasAuthorship W2999046935A5039338307 @default.
- W2999046935 hasAuthorship W2999046935A5041745890 @default.
- W2999046935 hasAuthorship W2999046935A5042184741 @default.
- W2999046935 hasAuthorship W2999046935A5065544431 @default.
- W2999046935 hasAuthorship W2999046935A5067676932 @default.
- W2999046935 hasAuthorship W2999046935A5080190120 @default.
- W2999046935 hasBestOaLocation W29990469351 @default.
- W2999046935 hasConcept C124490489 @default.
- W2999046935 hasConcept C126322002 @default.
- W2999046935 hasConcept C134018914 @default.
- W2999046935 hasConcept C136449434 @default.
- W2999046935 hasConcept C164027704 @default.
- W2999046935 hasConcept C179639408 @default.
- W2999046935 hasConcept C203014093 @default.
- W2999046935 hasConcept C2776070231 @default.
- W2999046935 hasConcept C2776914184 @default.
- W2999046935 hasConcept C2776940978 @default.
- W2999046935 hasConcept C2777379352 @default.
- W2999046935 hasConcept C2778653478 @default.
- W2999046935 hasConcept C2779740938 @default.
- W2999046935 hasConcept C71924100 @default.
- W2999046935 hasConcept C86803240 @default.
- W2999046935 hasConcept C8891405 @default.
- W2999046935 hasConceptScore W2999046935C124490489 @default.
- W2999046935 hasConceptScore W2999046935C126322002 @default.
- W2999046935 hasConceptScore W2999046935C134018914 @default.
- W2999046935 hasConceptScore W2999046935C136449434 @default.
- W2999046935 hasConceptScore W2999046935C164027704 @default.
- W2999046935 hasConceptScore W2999046935C179639408 @default.
- W2999046935 hasConceptScore W2999046935C203014093 @default.