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• W2999072004 abstract "The emblematic sponge Spongia officinalis is currently threatened by recurrent mortality incidents in its native habitats. Elevated temperature has been indicated as a major triggering factor, but the molecular mechanisms recruited for the organism’s response to thermal shifts are yet unknown. Here, we experimentally tested the effect of exposure to temperatures of varying intensity and span on its gene expression profile, replicating gradients encountered in the species’ native habitat. Analysis revealed major shifts in the organism’s transcriptomic profile induced by temperatures corresponding to the standard seasonal maximum, triggering processes related to signal transduction, inflammation and apoptotic pathway. Further elevation of temperature corresponding to local extremes activated further the immune response of the sponge along with protein ubiquitination. Following prolonged exposure, activation of endoplasmic reticulum stress related to accumulation of misfolded proteins and signs of resilience were observed. In the latter condition, categories such as cellular response to stress, wound repair, and diminution of pathological inflammation as also genes related to cell regeneration and cell growth were upregulated. Our results highlight the acknowledged sensitivity of S. officinalis to environmental shifts, providing an insight into the molecular mechanisms involved in the process. Furthermore, they suggest innate capacity for resilience at the current thermal extremes, implying a combination of factors and not temperature per se as the lethal agent. This sheds light on the mechanisms of pressure induced by the ongoing ocean warming trend to coastal sessile invertebrates." @default.
• W2999072004 created "2020-01-23" @default.
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• W2999072004 date "2020-01-10" @default.
• W2999072004 modified "2023-10-18" @default.
• W2999072004 title "Gearing Up for Warmer Times: Transcriptomic Response of Spongia officinalis to Elevated Temperatures Reveals Recruited Mechanisms and Potential for Resilience" @default.
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• W2999072004 cites W1763180691 @default.
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• W2999072004 cites W1968235571 @default.
• W2999072004 cites W1969353942 @default.
• W2999072004 cites W1977590108 @default.
• W2999072004 cites W1982646621 @default.
• W2999072004 cites W1983305704 @default.
• W2999072004 cites W1983610383 @default.
• W2999072004 cites W1986658525 @default.
• W2999072004 cites W1990960113 @default.
• W2999072004 cites W1992151646 @default.
• W2999072004 cites W1992245975 @default.
• W2999072004 cites W1994994529 @default.
• W2999072004 cites W1999574084 @default.
• W2999072004 cites W1999815031 @default.
• W2999072004 cites W2009179062 @default.
• W2999072004 cites W2011657487 @default.
• W2999072004 cites W2020445990 @default.
• W2999072004 cites W2020560563 @default.
• W2999072004 cites W2020831828 @default.
• W2999072004 cites W2027224845 @default.
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• W2999072004 cites W2038736651 @default.
• W2999072004 cites W2043831116 @default.
• W2999072004 cites W2050428763 @default.
• W2999072004 cites W2051875665 @default.
• W2999072004 cites W2055493690 @default.
• W2999072004 cites W2056624519 @default.
• W2999072004 cites W2057574729 @default.
• W2999072004 cites W2065861852 @default.
• W2999072004 cites W2068194085 @default.
• W2999072004 cites W2069201244 @default.
• W2999072004 cites W2069912641 @default.
• W2999072004 cites W2071806815 @default.
• W2999072004 cites W2076638437 @default.
• W2999072004 cites W2083183446 @default.
• W2999072004 cites W2089247101 @default.
• W2999072004 cites W2090217389 @default.
• W2999072004 cites W2092449313 @default.
• W2999072004 cites W2096486640 @default.
• W2999072004 cites W2096988482 @default.
• W2999072004 cites W2103235098 @default.
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• W2999072004 cites W2132120234 @default.
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• W2999072004 cites W2147618358 @default.
• W2999072004 cites W2151632180 @default.
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• W2999072004 cites W2155628349 @default.
• W2999072004 cites W2158903457 @default.
• W2999072004 cites W2162515328 @default.
• W2999072004 cites W2164154943 @default.
• W2999072004 cites W2165310182 @default.
• W2999072004 cites W2168896600 @default.
• W2999072004 cites W2170551349 @default.
• W2999072004 cites W2325880234 @default.
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• W2999072004 doi "https://doi.org/10.3389/fmars.2019.00786" @default.
• W2999072004 hasPublicationYear "2020" @default.
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