Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999102712> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2999102712 abstract "The huge impact of cancer is a big concern nowadays. Protein Kinases (PKCs) are attractive anticancer targets due to their involvement in several processes of carcinogenesis. Particularly, the isoform δ (PKC-δ) acts as tumor suppressor in colon cancer, one of the most dominant cancers and cause of cancer mortality worldwide [1]. Promising bioactive molecules were found in Plectranthus genus, mainly diterpene royleanones [1, 2]. The 7α-acetoxy-6β-hydroxyroyleanone (Roy) is the major constituent of P. grandidentatus acetonic extracts. Several biological activities of Roy were reported in the literature, including antitumoral activity [3]. Moreover, the presence of two free hydroxyl groups (position C-6 and C12) in Roy structure drawn our attention to the possibility of preparing new derivatives with enhanced cytotoxic activity. In fact, in a previous work, the patented diterpene 6β-benzoyloxy-12-O-benzoylroyleanone (RoyBz) [3], shown selective activation of PKC-δ [5]. The aim of the present work is to prepare new potential PKC-δ activators from derivatization of Roy. Thus, Roy and RoyBz assisted the design of theoretical derivatives, through modification of C-12 and C-6 hydroxyl groups. Molecular docking simulations were carried out against the 3D structure of human PKC-δ regulatory domain, to identify the potential PKC-δ activators. The most promising compounds accepted by docking simulations are currently been prepared by hemi-synthesis using Roy as starting material for structure-activity relationships. References: [1]. Ladeiras D et al. (2016) Curr. Pharm. Des. 22 (12): 1682.[2]. Matias D et al. (2019) ACS Omega. 4: 8094.[3]. Bernardes CES et al. (2018) Mol. Pharm. 15 (4): 1412.[4]. Saraiva L et al., “Roy-Bz: a small molecule activator of Protein Kinase Cdelta (PKCDelta)” Patent Ref PCT/IB2017/050633.[5]. Bessa C et al., Cell Death Dis. 2018, Vol. 9." @default.
- W2999102712 created "2020-01-23" @default.
- W2999102712 creator A5009993589 @default.
- W2999102712 creator A5012111165 @default.
- W2999102712 creator A5035375779 @default.
- W2999102712 creator A5056521107 @default.
- W2999102712 creator A5059788934 @default.
- W2999102712 creator A5062260507 @default.
- W2999102712 creator A5071370272 @default.
- W2999102712 creator A5079680190 @default.
- W2999102712 creator A5001571076 @default.
- W2999102712 creator A5006824142 @default.
- W2999102712 date "2019-10-30" @default.
- W2999102712 modified "2023-10-16" @default.
- W2999102712 title "Design and molecular docking studies of new potential PKC-δ activators based on royleanone scaffold" @default.
- W2999102712 doi "https://doi.org/10.3390/ecmc2019-06297" @default.
- W2999102712 hasPublicationYear "2019" @default.
- W2999102712 type Work @default.
- W2999102712 sameAs 2999102712 @default.
- W2999102712 citedByCount "0" @default.
- W2999102712 crossrefType "proceedings-article" @default.
- W2999102712 hasAuthorship W2999102712A5001571076 @default.
- W2999102712 hasAuthorship W2999102712A5006824142 @default.
- W2999102712 hasAuthorship W2999102712A5009993589 @default.
- W2999102712 hasAuthorship W2999102712A5012111165 @default.
- W2999102712 hasAuthorship W2999102712A5035375779 @default.
- W2999102712 hasAuthorship W2999102712A5056521107 @default.
- W2999102712 hasAuthorship W2999102712A5059788934 @default.
- W2999102712 hasAuthorship W2999102712A5062260507 @default.
- W2999102712 hasAuthorship W2999102712A5071370272 @default.
- W2999102712 hasAuthorship W2999102712A5079680190 @default.
- W2999102712 hasConcept C115302286 @default.
- W2999102712 hasConcept C159110408 @default.
- W2999102712 hasConcept C184235292 @default.
- W2999102712 hasConcept C185592680 @default.
- W2999102712 hasConcept C195794163 @default.
- W2999102712 hasConcept C2776710815 @default.
- W2999102712 hasConcept C41685203 @default.
- W2999102712 hasConcept C55493867 @default.
- W2999102712 hasConcept C70721500 @default.
- W2999102712 hasConcept C71240020 @default.
- W2999102712 hasConcept C71924100 @default.
- W2999102712 hasConcept C86803240 @default.
- W2999102712 hasConceptScore W2999102712C115302286 @default.
- W2999102712 hasConceptScore W2999102712C159110408 @default.
- W2999102712 hasConceptScore W2999102712C184235292 @default.
- W2999102712 hasConceptScore W2999102712C185592680 @default.
- W2999102712 hasConceptScore W2999102712C195794163 @default.
- W2999102712 hasConceptScore W2999102712C2776710815 @default.
- W2999102712 hasConceptScore W2999102712C41685203 @default.
- W2999102712 hasConceptScore W2999102712C55493867 @default.
- W2999102712 hasConceptScore W2999102712C70721500 @default.
- W2999102712 hasConceptScore W2999102712C71240020 @default.
- W2999102712 hasConceptScore W2999102712C71924100 @default.
- W2999102712 hasConceptScore W2999102712C86803240 @default.
- W2999102712 hasLocation W29991027121 @default.
- W2999102712 hasOpenAccess W2999102712 @default.
- W2999102712 hasPrimaryLocation W29991027121 @default.
- W2999102712 hasRelatedWork W1970974546 @default.
- W2999102712 hasRelatedWork W1973158505 @default.
- W2999102712 hasRelatedWork W1985621657 @default.
- W2999102712 hasRelatedWork W2050829851 @default.
- W2999102712 hasRelatedWork W2071701832 @default.
- W2999102712 hasRelatedWork W2077200453 @default.
- W2999102712 hasRelatedWork W2156394477 @default.
- W2999102712 hasRelatedWork W2807746438 @default.
- W2999102712 hasRelatedWork W2809711747 @default.
- W2999102712 hasRelatedWork W4320926475 @default.
- W2999102712 isParatext "false" @default.
- W2999102712 isRetracted "false" @default.
- W2999102712 magId "2999102712" @default.
- W2999102712 workType "article" @default.