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- W2999138873 abstract "Knocking out a chromatin factor often does not alter the transcription of its binding targets. What explains the observed disconnect between binding and effect? We hypothesize that this discrepancy could be associated with the role of chromatin factors in maintaining genetic and epigenetic integrity at promoters, and not necessarily with transcription. Through re‐analysis of published datasets, we present several lines of evidence that support our hypothesis and deflate the popular assumptions. We also tested the hypothesis through mutation accumulation assays on yeast knockouts of chromatin factors. Altogether, the proposed hypothesis presents a simple explanation for the global discord between chromatin factor binding and effect. Future work in this direction might fortify the hypothesis and elucidate the underlying mechanisms." @default.
- W2999138873 created "2020-01-23" @default.
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- W2999138873 creator A5071369024 @default.
- W2999138873 creator A5089859455 @default.
- W2999138873 date "2020-01-29" @default.
- W2999138873 modified "2023-09-27" @default.
- W2999138873 title "Does genome surveillance explain the global discrepancy between binding and effect of chromatin factors?" @default.
- W2999138873 cites W1524263391 @default.
- W2999138873 cites W1530768309 @default.
- W2999138873 cites W1644052592 @default.
- W2999138873 cites W1965768609 @default.
- W2999138873 cites W1967517944 @default.
- W2999138873 cites W1967851694 @default.
- W2999138873 cites W1968804305 @default.
- W2999138873 cites W1968916935 @default.
- W2999138873 cites W1968917541 @default.
- W2999138873 cites W1969503475 @default.
- W2999138873 cites W1973175445 @default.
- W2999138873 cites W1976471430 @default.
- W2999138873 cites W1977316264 @default.
- W2999138873 cites W1978189157 @default.
- W2999138873 cites W1979540894 @default.
- W2999138873 cites W1984866675 @default.
- W2999138873 cites W1988754209 @default.
- W2999138873 cites W1988968994 @default.
- W2999138873 cites W1995139737 @default.
- W2999138873 cites W1997303368 @default.
- W2999138873 cites W1997974981 @default.
- W2999138873 cites W2001294950 @default.
- W2999138873 cites W2001360952 @default.
- W2999138873 cites W2002428253 @default.
- W2999138873 cites W2008616402 @default.
- W2999138873 cites W2014339767 @default.
- W2999138873 cites W2014696364 @default.
- W2999138873 cites W2016608274 @default.
- W2999138873 cites W2019025864 @default.
- W2999138873 cites W2029521343 @default.
- W2999138873 cites W2032657745 @default.
- W2999138873 cites W2036477200 @default.
- W2999138873 cites W2036504531 @default.
- W2999138873 cites W2048186818 @default.
- W2999138873 cites W2051756496 @default.
- W2999138873 cites W2055320236 @default.
- W2999138873 cites W2060141490 @default.
- W2999138873 cites W2067393096 @default.
- W2999138873 cites W2068533511 @default.
- W2999138873 cites W2072404701 @default.
- W2999138873 cites W2080564499 @default.
- W2999138873 cites W2081117751 @default.
- W2999138873 cites W2086524378 @default.
- W2999138873 cites W2089827566 @default.
- W2999138873 cites W2090438862 @default.
- W2999138873 cites W2093814864 @default.
- W2999138873 cites W2095120904 @default.
- W2999138873 cites W2102173037 @default.
- W2999138873 cites W2103453943 @default.
- W2999138873 cites W2118937292 @default.
- W2999138873 cites W2118997256 @default.
- W2999138873 cites W2121907028 @default.
- W2999138873 cites W2126684428 @default.
- W2999138873 cites W2127180680 @default.
- W2999138873 cites W2127995667 @default.
- W2999138873 cites W2128255364 @default.
- W2999138873 cites W2129131697 @default.
- W2999138873 cites W2129707839 @default.
- W2999138873 cites W2133102806 @default.
- W2999138873 cites W2133123145 @default.
- W2999138873 cites W2137683543 @default.
- W2999138873 cites W2144688273 @default.
- W2999138873 cites W2149683434 @default.
- W2999138873 cites W2154046032 @default.
- W2999138873 cites W2158450754 @default.
- W2999138873 cites W2158714788 @default.
- W2999138873 cites W2160444267 @default.
- W2999138873 cites W2162832688 @default.
- W2999138873 cites W2166182744 @default.
- W2999138873 cites W2167261518 @default.
- W2999138873 cites W2168237762 @default.
- W2999138873 cites W2168333121 @default.
- W2999138873 cites W2212660163 @default.
- W2999138873 cites W2219799225 @default.
- W2999138873 cites W2256829667 @default.
- W2999138873 cites W2320269984 @default.
- W2999138873 cites W2329939076 @default.
- W2999138873 cites W2339240569 @default.
- W2999138873 cites W2341857359 @default.
- W2999138873 cites W2406576771 @default.
- W2999138873 cites W2425965912 @default.
- W2999138873 cites W2520470932 @default.
- W2999138873 cites W2530492937 @default.
- W2999138873 cites W2531931752 @default.
- W2999138873 cites W2566792521 @default.
- W2999138873 cites W2618807644 @default.
- W2999138873 cites W2620709666 @default.