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- W2999154355 abstract "While the GAS M protein has been the leading vaccine target for decades, the bacteria encode many other virulence factors of interest for vaccine development. In this work, we show that emm -like genes are encoded in a remarkable majority of GAS genomes and expressed at a level similar to that for the emm gene. In collaboration with the U.S. Centers for Disease Control, we developed molecular definitions of the different emm and emm -like gene families. This clarification should abrogate mistyping of strains, especially in the area of whole-genome typing. We have also updated the emm -typing collection by removing emm -like gene sequences and provided in-depth analysis of Mrp and Enn protein sequence structure and diversity." @default.
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- W2999154355 date "2020-02-26" @default.
- W2999154355 modified "2023-10-18" @default.
- W2999154355 title "Analysis of Global Collection of Group A <i>Streptococcus</i> Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins" @default.
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- W2999154355 doi "https://doi.org/10.1128/msphere.00806-19" @default.
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