FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999179630> ?p ?o ?g. }

• W2999179630 endingPage "673" @default.
• W2999179630 startingPage "662" @default.
• W2999179630 abstract "Prior candidate gene studies have shown tumor suppressor DNA methylation in breast milk related with history of breast biopsy, an established risk factor for breast cancer. To further establish the utility of breast milk as a tissue-specific biospecimen for investigations of breast carcinogenesis, we measured genome-wide DNA methylation in breast milk from women with and without a diagnosis of breast cancer in two independent cohorts. DNA methylation was assessed using Illumina HumanMethylation450k in 87 breast milk samples. Through an epigenome-wide association study we explored CpG sites associated with a breast cancer diagnosis in the prospectively collected milk samples from the breast that would develop cancer compared with women without a diagnosis of breast cancer using linear mixed effects models adjusted for history of breast biopsy, age, RefFreeCellMix cell estimates, time of delivery, array chip and subject as random effect. We identified 58 differentially methylated CpG sites associated with a subsequent breast cancer diagnosis (q-value <0.05). Nearly all CpG sites associated with a breast cancer diagnosis were hypomethylated in cases compared with controls and were enriched for CpG islands. In addition, inferred repeat element methylation was lower in breast milk DNA from cases compared to controls, and cases exhibited increased estimated epigenetic mitotic tick rate as well as DNA methylation age compared with controls. Breast milk has utility as a biospecimen for prospective assessment of disease risk, for understanding the underlying molecular basis of breast cancer risk factors and improving primary and secondary prevention of breast cancer." @default.
• W2999179630 created "2020-01-23" @default.
• W2999179630 creator A5018847026 @default.
• W2999179630 creator A5056163853 @default.
• W2999179630 creator A5060557907 @default.
• W2999179630 creator A5062649421 @default.
• W2999179630 creator A5067544447 @default.
• W2999179630 creator A5071012007 @default.
• W2999179630 creator A5081393377 @default.
• W2999179630 creator A5082545896 @default.
• W2999179630 date "2020-01-16" @default.
• W2999179630 modified "2023-10-14" @default.
• W2999179630 title "Prediagnostic breast milk DNA methylation alterations in women who develop breast cancer" @default.
• W2999179630 cites W1574942062 @default.
• W2999179630 cites W1973051534 @default.
• W2999179630 cites W1974047233 @default.
• W2999179630 cites W1977355465 @default.
• W2999179630 cites W1985904922 @default.
• W2999179630 cites W2008063143 @default.
• W2999179630 cites W2010457001 @default.
• W2999179630 cites W2011773129 @default.
• W2999179630 cites W2028647698 @default.
• W2999179630 cites W2056040742 @default.
• W2999179630 cites W2063754654 @default.
• W2999179630 cites W2068536063 @default.
• W2999179630 cites W2079565561 @default.
• W2999179630 cites W2085442947 @default.
• W2999179630 cites W2085832350 @default.
• W2999179630 cites W2099343472 @default.
• W2999179630 cites W2099828433 @default.
• W2999179630 cites W2101870168 @default.
• W2999179630 cites W2108421119 @default.
• W2999179630 cites W2119883345 @default.
• W2999179630 cites W2125342106 @default.
• W2999179630 cites W2129915465 @default.
• W2999179630 cites W2146512944 @default.
• W2999179630 cites W2156295630 @default.
• W2999179630 cites W2157834732 @default.
• W2999179630 cites W2160078219 @default.
• W2999179630 cites W2163640326 @default.
• W2999179630 cites W2165664908 @default.
• W2999179630 cites W2261451134 @default.
• W2999179630 cites W2293127545 @default.
• W2999179630 cites W2315357980 @default.
• W2999179630 cites W2323381934 @default.
• W2999179630 cites W2341232748 @default.
• W2999179630 cites W2341474791 @default.
• W2999179630 cites W2461781757 @default.
• W2999179630 cites W2507799542 @default.
• W2999179630 cites W2508096274 @default.
• W2999179630 cites W2510028826 @default.
• W2999179630 cites W2529317472 @default.
• W2999179630 cites W2537310520 @default.
• W2999179630 cites W2586938441 @default.
• W2999179630 cites W2599690763 @default.
• W2999179630 cites W2625029673 @default.
• W2999179630 cites W2725163236 @default.
• W2999179630 cites W2732950170 @default.
• W2999179630 cites W2735900593 @default.
• W2999179630 cites W2736295157 @default.
• W2999179630 cites W2781492719 @default.
• W2999179630 cites W2800918431 @default.
• W2999179630 cites W2805049578 @default.
• W2999179630 cites W2886752110 @default.
• W2999179630 cites W2890195818 @default.
• W2999179630 cites W2911188335 @default.
• W2999179630 cites W2917830189 @default.
• W2999179630 cites W2951545629 @default.
• W2999179630 cites W2972097997 @default.
• W2999179630 cites W2999179630 @default.
• W2999179630 cites W81443339 @default.
• W2999179630 doi "https://doi.org/10.1093/hmg/ddz301" @default.
• W2999179630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7068171" @default.
• W2999179630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31943067" @default.
• W2999179630 hasPublicationYear "2020" @default.
• W2999179630 type Work @default.
• W2999179630 sameAs 2999179630 @default.
• W2999179630 citedByCount "12" @default.
• W2999179630 countsByYear W29991796302020 @default.
• W2999179630 countsByYear W29991796302021 @default.
• W2999179630 countsByYear W29991796302022 @default.
• W2999179630 countsByYear W29991796302023 @default.
• W2999179630 crossrefType "journal-article" @default.
• W2999179630 hasAuthorship W2999179630A5018847026 @default.
• W2999179630 hasAuthorship W2999179630A5056163853 @default.
• W2999179630 hasAuthorship W2999179630A5060557907 @default.
• W2999179630 hasAuthorship W2999179630A5062649421 @default.
• W2999179630 hasAuthorship W2999179630A5067544447 @default.
• W2999179630 hasAuthorship W2999179630A5071012007 @default.
• W2999179630 hasAuthorship W2999179630A5081393377 @default.
• W2999179630 hasAuthorship W2999179630A5082545896 @default.
• W2999179630 hasBestOaLocation W29991796301 @default.
• W2999179630 hasConcept C104317684 @default.
• W2999179630 hasConcept C121608353 @default.
• W2999179630 hasConcept C126322002 @default.
• W2999179630 hasConcept C140173407 @default.
• W2999179630 hasConcept C143998085 @default.
• W2999179630 hasConcept C150194340 @default.

• next