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- W2999216129 abstract "BackgroundHypoxia is a common feature of rapidly growing solid tumors. Therefore, cellular adaptation to hypoxia and altered glucose metabolism are fundamental to the biology of cancer cells. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor for more than 60 genes recognized to control the delivery of oxygen and nutrients through the induction of angiogenesis and glycolysis under hypoxic conditions. Therefore, inhibition of the expression of HIF-1α can be expected to be potentially tumor-specific molecular target-based therapy. In this study, we evaluated the significance of HIF-1α expression in relationship to clinicopathological factors, prognosis, vascular endothelial growth factor (VEGF) expression, and microvessel density (MVD)." @default.
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- W2999216129 date "2012-09-01" @default.
- W2999216129 modified "2023-09-28" @default.
- W2999216129 title "Clinicopathological Significance of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) Expression in Gastric Cancer" @default.
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- W2999216129 doi "https://doi.org/10.1016/s0923-7534(20)33333-0" @default.
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