FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999224819> ?p ?o ?g. }

• W2999224819 endingPage "S208" @default.
• W2999224819 startingPage "S207" @default.
• W2999224819 abstract "Abstract Background Patients with IBD are at higher risk for non-alcoholic fatty liver disease (NAFLD) comparing to general population. Complex pathogenesis of NAFLD in IBD may be related to disease-specific risk factors such as chronic inflammation, steroid exposure, drug induced hepatotoxicity, malnutrition and alteration of gut microbiota, which is emerging as a major factor in the pathogenesis of NAFLD. The goal of the study was to investigate factors associated with NADLF and advanced liver fibrosis (ALF) in patients with CD and UC. Methods This is a retrospective study on IBD patients without extraintestinal manifestations and known liver disease. NAFLD was defined as Hepatic Steatosis Index (HSI) ≥ 36, and ALF was defined as FIB-4 ≥ 2.67. Predictors of NAFLD development were analysed using Kaplan–Meier and Cox regression analyses. Results In this retrospective study, we have included 225 IBD patients; 72.4% (n = 163) patients with CD and 27.6% (n = 62) patients with UC (median age 41.2 yr, 53.7% males) which were observed for a median of 4.6 years. There were 63.1% (n = 142) patients with normal BMI, 27.6% (n = 62) overweight and 9.3% (n = 21) obese patients. Obese patients had the highest HIS score 43.9 ± 5.9, following with overweight 37.8 ± 5.7 and normal BMI 30 ± 4.3 kg/m2, p &lt; 0.001. During the follow-up obese and overweight patients had higher risk of developing NAFLD comparing to patients with normal BMI (obese HR = 11.1 95% CI 4.3–28.3 and overweight HR = 5.55 95% CI 3.4–9.1, Logrank test p &lt; 0.001) (Figure 1). Regarding FIB-4 score there, was no difference among different BMI categories (p = 0.192), and there was no difference in ALF development in the follow-up period (Logrank test p = 0.91). In Cox proportional-hazards regression significant predictors for NAFLD development were dyslipidaemia HR=2.11, 95% CI 1.2–3.7, overweight HR=6 95% CI 3.6–10, and obesity HR=13.4, 95% CI 7–35. Conclusion NAFLD is frequent comorbidity in patients with CD and UC, which can lead to development of advanced liver fibrosis. Our results show that patients with IBD have a high risk of NAFLD development, whereas the increased risk for ALF was not observed. Overweight and obese patients and those with dyslipidemia should be closer monitored due to significantly higher risk of NAFLD. This study points out the complexity disease-specific risk factors and importance of better stratifying IBD patients at risk of NAFLD and advanced liver fibrosis." @default.
• W2999224819 created "2020-01-23" @default.
• W2999224819 creator A5002798831 @default.
• W2999224819 creator A5009822796 @default.
• W2999224819 creator A5010617734 @default.
• W2999224819 creator A5020927715 @default.
• W2999224819 creator A5067689210 @default.
• W2999224819 creator A5068388301 @default.
• W2999224819 creator A5068621002 @default.
• W2999224819 creator A5084228410 @default.
• W2999224819 creator A5089851137 @default.
• W2999224819 date "2020-01-01" @default.
• W2999224819 modified "2023-10-11" @default.
• W2999224819 title "P140 Factors associated with development of NAFLD in patients with inflammatory bowel disease: a 5-year retrospective study on 225 patients" @default.
• W2999224819 doi "https://doi.org/10.1093/ecco-jcc/jjz203.269" @default.
• W2999224819 hasPublicationYear "2020" @default.
• W2999224819 type Work @default.
• W2999224819 sameAs 2999224819 @default.
• W2999224819 citedByCount "2" @default.
• W2999224819 countsByYear W29992248192023 @default.
• W2999224819 crossrefType "journal-article" @default.
• W2999224819 hasAuthorship W2999224819A5002798831 @default.
• W2999224819 hasAuthorship W2999224819A5009822796 @default.
• W2999224819 hasAuthorship W2999224819A5010617734 @default.
• W2999224819 hasAuthorship W2999224819A5020927715 @default.
• W2999224819 hasAuthorship W2999224819A5067689210 @default.
• W2999224819 hasAuthorship W2999224819A5068388301 @default.
• W2999224819 hasAuthorship W2999224819A5068621002 @default.
• W2999224819 hasAuthorship W2999224819A5084228410 @default.
• W2999224819 hasAuthorship W2999224819A5089851137 @default.
• W2999224819 hasBestOaLocation W29992248191 @default.
• W2999224819 hasConcept C126322002 @default.
• W2999224819 hasConcept C167135981 @default.
• W2999224819 hasConcept C2776175330 @default.
• W2999224819 hasConcept C2778260677 @default.
• W2999224819 hasConcept C2778772119 @default.
• W2999224819 hasConcept C2779134260 @default.
• W2999224819 hasConcept C2780221984 @default.
• W2999224819 hasConcept C2780586474 @default.
• W2999224819 hasConcept C2780942790 @default.
• W2999224819 hasConcept C2908647359 @default.
• W2999224819 hasConcept C50440223 @default.
• W2999224819 hasConcept C511355011 @default.
• W2999224819 hasConcept C71924100 @default.
• W2999224819 hasConcept C90924648 @default.
• W2999224819 hasConcept C99454951 @default.
• W2999224819 hasConceptScore W2999224819C126322002 @default.
• W2999224819 hasConceptScore W2999224819C167135981 @default.
• W2999224819 hasConceptScore W2999224819C2776175330 @default.
• W2999224819 hasConceptScore W2999224819C2778260677 @default.
• W2999224819 hasConceptScore W2999224819C2778772119 @default.
• W2999224819 hasConceptScore W2999224819C2779134260 @default.
• W2999224819 hasConceptScore W2999224819C2780221984 @default.
• W2999224819 hasConceptScore W2999224819C2780586474 @default.
• W2999224819 hasConceptScore W2999224819C2780942790 @default.
• W2999224819 hasConceptScore W2999224819C2908647359 @default.
• W2999224819 hasConceptScore W2999224819C50440223 @default.
• W2999224819 hasConceptScore W2999224819C511355011 @default.
• W2999224819 hasConceptScore W2999224819C71924100 @default.
• W2999224819 hasConceptScore W2999224819C90924648 @default.
• W2999224819 hasConceptScore W2999224819C99454951 @default.
• W2999224819 hasIssue "Supplement_1" @default.
• W2999224819 hasLocation W29992248191 @default.
• W2999224819 hasOpenAccess W2999224819 @default.
• W2999224819 hasPrimaryLocation W29992248191 @default.
• W2999224819 hasRelatedWork W118235694 @default.
• W2999224819 hasRelatedWork W1866091461 @default.
• W2999224819 hasRelatedWork W2047277250 @default.
• W2999224819 hasRelatedWork W2063325699 @default.
• W2999224819 hasRelatedWork W206606740 @default.
• W2999224819 hasRelatedWork W2735939940 @default.
• W2999224819 hasRelatedWork W2777447650 @default.
• W2999224819 hasRelatedWork W2999224819 @default.
• W2999224819 hasRelatedWork W4220656069 @default.
• W2999224819 hasRelatedWork W4289816235 @default.
• W2999224819 hasVolume "14" @default.
• W2999224819 isParatext "false" @default.
• W2999224819 isRetracted "false" @default.
• W2999224819 magId "2999224819" @default.
• W2999224819 workType "article" @default.