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- W2999236498 abstract "Objective: This study aimed to explore the association between monoaminergic genetic variants and emotional lability (EL) symptoms in children with ADHD. In addition, genetic effects on prefrontal cortex (PFC)-amygdala functional connectivity (FC) were investigated. Method: Children with ADHD and controls were genotyped for five monoaminergic genetic variants and were evaluated for EL symptoms. Imaging genetic exploration was conducted with previously reported aberrant PFC-amygdala resting-state functional connectivities (RSFCs) as target features. Results: A genotypic effect on EL symptoms was only found for NET1-rs3785143, indicating higher EL symptoms in TT genotype carriers than in C-allele carriers. Imaging genetic analyses indicated a marginal effect of NET1-rs3785143 on ADHD-altered FC between the superficial amygdala (SFA) and middle frontal gyrus (MFG). Mediation analysis suggested potential effects of NET1-rs3785143 via RSFC (SFA-MFG) on EL. Conclusion:NET1 variants might participate in the pathogenesis of EL in children with ADHD by influencing the function of the PFC-amygdala circuit." @default.
- W2999236498 created "2020-01-23" @default.
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- W2999236498 date "2020-01-08" @default.
- W2999236498 modified "2023-10-18" @default.
- W2999236498 title "Monoaminergic Genetic Variants, Prefrontal Cortex–Amygdala Circuit, and Emotional Symptoms in Children With ADHD: Exploration Based on the Gene–Brain–Behavior Relationship" @default.
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- W2999236498 doi "https://doi.org/10.1177/1087054719897838" @default.
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