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• W2999279594 abstract "Abstract Background The relative influence of diet and phylogeny on snake venom activity is a poorly understood aspect of snake venom evolution. We measured the activity of two enzyme toxin groups – phospholipase A 2 (PLA 2 ), and L-amino acid oxidase (LAAO) – in the venom of 39 species of Australian elapids (40% of terrestrial species diversity) and used linear parsimony and BayesTraits to investigate any correlation between enzyme activity and phylogeny or diet. Results PLA 2 activity ranged from 0 to 481 nmol/min/mg of venom, and LAAO activity ranged from 0 to 351 nmol/min/mg. Phylogenetic comparative methods, implemented in BayesTraits showed that enzyme activity was strongly correlated with phylogeny, more so for LAAO activity. For example, LAAO activity was absent in both the Vermicella and Pseudonaja/Oxyuranus clade, supporting previously proposed relationships among these disparate taxa. There was no association between broad dietary categories and either enzyme activity. There was strong evidence for faster initial rates of change over evolutionary time for LAAO (delta parameter mean 0.2), but no such pattern in PLA 2 (delta parameter mean 0.64). There were some exceptions to the phylogenetic patterns of enzyme activity: different PLA 2 activity in the ecologically similar sister-species Denisonia devisi and D. maculata ; large inter-specific differences in PLA 2 activity in Hoplocephalus and Austrelaps . Conclusions We have shown that phylogeny is a stronger influence on venom enzyme activity than diet for two of the four major enzyme families present in snake venoms. PLA 2 and LAAO activities had contrasting evolutionary dynamics with the higher delta value for PLA 2 Some species/individuals lacked activity in one protein family suggesting that the loss of single protein family may not incur a significant fitness cost." @default.
• W2999279594 created "2020-01-23" @default.
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• W2999279594 date "2020-01-13" @default.
• W2999279594 modified "2023-09-30" @default.
• W2999279594 title "Activity of two key toxin groups in Australian elapid venoms show a strong correlation to phylogeny but not to diet" @default.
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• W2999279594 doi "https://doi.org/10.1186/s12862-020-1578-x" @default.
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