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- W2999291738 abstract "The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-tropical countries. This bacterium occupies broad ecological niches including soil, contaminated water, single-cell microbes, plants and infection in a range of animal species. Here, we performed genome-wide association studies for genetic determinants of environmental and human adaptation using a combined dataset of 1,010 whole genome sequences of B. pseudomallei from Northeast Thailand and Australia, representing two major disease hotspots. With these data, we identified 47 genes from 26 distinct loci associated with clinical or environmental isolates from Thailand and replicated 12 genes in an independent Australian cohort. We next outlined the selective pressures on the genetic loci (dN/dS) and the frequency at which they had been gained or lost throughout their evolutionary history, reflecting the bacterial adaptability to a wide range of ecological niches. Finally, we highlighted loci likely implicated in human disease. Claire Chewapreecha et al. combine 753 newly sequenced Thai Burkholderia pseudomallei isolates with 258 Australian isolates to identify genes associated with either clinical or environmental strains. They find 47 genes, 12 of which replicate in both locations, that may provide clues to the strategy used by this microbe to adapt to survive in wide range of ecological niches, including human hosts." @default.
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- W2999291738 date "2019-11-22" @default.
- W2999291738 modified "2023-09-24" @default.
- W2999291738 title "Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei." @default.
- W2999291738 doi "https://doi.org/10.17863/cam.47535" @default.
- W2999291738 hasPublicationYear "2019" @default.
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