Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999298927> ?p ?o ?g. }
- W2999298927 endingPage "2553" @default.
- W2999298927 startingPage "2544" @default.
- W2999298927 abstract "Colorectal cancer (CRC) is one of the most common cancers worldwide. Despite advances in treatment, no treatment modality specific for the different CRC phenotypes has been developed. BMI1 has been previously reported to play an important role in the regulation of cancer stem cells and cell cycle in CRC. However, the role of BMI1 in individualized treatment for CRC is largely unknown. In this study, we found that the apoptotic effect of paclitaxel is more profound in BMI1-depleted cells. The apoptotic effect is exerted by promoting caspase-8-independent apoptotic pathways after combination with paclitaxel in BMI1 knockdown cells. This effect could be totally recovered by pretreatment with caspase inhibitor compared with caspase-8 inhibitor alone. It has been reported that the levels of MCL-1 play a role in regulating cell resistance to paclitaxel treatment. Our data indicated that the downregulation of MCL-1 through the activation of GSK3beta and JNK is driven by BMI1 depletion. Consistent with in vitro data, a synergic anti-growth effect of BMI1 depletion with paclitaxel treatment was shown in vivo. In conclusion, paclitaxel has a stronger suppressive effect on tumor growth and proliferation in CRC with low BMI1 expression. Thus, in CRC patients, paclitaxel could be specifically indicated for patients with low BMI1 expression." @default.
- W2999298927 created "2020-01-23" @default.
- W2999298927 creator A5000315935 @default.
- W2999298927 creator A5022940704 @default.
- W2999298927 creator A5030779425 @default.
- W2999298927 creator A5050803233 @default.
- W2999298927 creator A5052297762 @default.
- W2999298927 creator A5053604127 @default.
- W2999298927 creator A5079127096 @default.
- W2999298927 creator A5087856776 @default.
- W2999298927 creator A5089886091 @default.
- W2999298927 date "2019-01-01" @default.
- W2999298927 modified "2023-09-25" @default.
- W2999298927 title "Impact of BMI1 expression on the apoptotic effect of paclitaxel in colorectal cancer." @default.
- W2999298927 cites W1595263809 @default.
- W2999298927 cites W1823288226 @default.
- W2999298927 cites W1964481452 @default.
- W2999298927 cites W1977258127 @default.
- W2999298927 cites W1982254984 @default.
- W2999298927 cites W1989399038 @default.
- W2999298927 cites W1994918739 @default.
- W2999298927 cites W2008553730 @default.
- W2999298927 cites W2011234475 @default.
- W2999298927 cites W2022662750 @default.
- W2999298927 cites W2029276420 @default.
- W2999298927 cites W2031100904 @default.
- W2999298927 cites W2037758170 @default.
- W2999298927 cites W2053217945 @default.
- W2999298927 cites W2055397209 @default.
- W2999298927 cites W2057390343 @default.
- W2999298927 cites W2058210195 @default.
- W2999298927 cites W2061776806 @default.
- W2999298927 cites W2069284062 @default.
- W2999298927 cites W2076107775 @default.
- W2999298927 cites W2084192782 @default.
- W2999298927 cites W2088802752 @default.
- W2999298927 cites W2090970397 @default.
- W2999298927 cites W2092894835 @default.
- W2999298927 cites W2093628776 @default.
- W2999298927 cites W2106548070 @default.
- W2999298927 cites W2111851685 @default.
- W2999298927 cites W2112036872 @default.
- W2999298927 cites W2123122199 @default.
- W2999298927 cites W2133190342 @default.
- W2999298927 cites W2139505515 @default.
- W2999298927 cites W2147834058 @default.
- W2999298927 cites W2150048195 @default.
- W2999298927 cites W2156583045 @default.
- W2999298927 cites W2158257131 @default.
- W2999298927 cites W2165948908 @default.
- W2999298927 cites W2166222647 @default.
- W2999298927 cites W2412555151 @default.
- W2999298927 cites W2517055328 @default.
- W2999298927 cites W2557187041 @default.
- W2999298927 cites W2594373254 @default.
- W2999298927 cites W2595733006 @default.
- W2999298927 cites W2760240652 @default.
- W2999298927 cites W2887408433 @default.
- W2999298927 cites W2893318139 @default.
- W2999298927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6895441" @default.
- W2999298927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31815052" @default.
- W2999298927 hasPublicationYear "2019" @default.
- W2999298927 type Work @default.
- W2999298927 sameAs 2999298927 @default.
- W2999298927 citedByCount "4" @default.
- W2999298927 countsByYear W29992989272020 @default.
- W2999298927 countsByYear W29992989272022 @default.
- W2999298927 crossrefType "journal-article" @default.
- W2999298927 hasAuthorship W2999298927A5000315935 @default.
- W2999298927 hasAuthorship W2999298927A5022940704 @default.
- W2999298927 hasAuthorship W2999298927A5030779425 @default.
- W2999298927 hasAuthorship W2999298927A5050803233 @default.
- W2999298927 hasAuthorship W2999298927A5052297762 @default.
- W2999298927 hasAuthorship W2999298927A5053604127 @default.
- W2999298927 hasAuthorship W2999298927A5079127096 @default.
- W2999298927 hasAuthorship W2999298927A5087856776 @default.
- W2999298927 hasAuthorship W2999298927A5089886091 @default.
- W2999298927 hasConcept C104317684 @default.
- W2999298927 hasConcept C121608353 @default.
- W2999298927 hasConcept C12519072 @default.
- W2999298927 hasConcept C126322002 @default.
- W2999298927 hasConcept C127561419 @default.
- W2999298927 hasConcept C143998085 @default.
- W2999298927 hasConcept C150903083 @default.
- W2999298927 hasConcept C173396325 @default.
- W2999298927 hasConcept C190283241 @default.
- W2999298927 hasConcept C207001950 @default.
- W2999298927 hasConcept C2777292972 @default.
- W2999298927 hasConcept C2778987575 @default.
- W2999298927 hasConcept C29537977 @default.
- W2999298927 hasConcept C31573885 @default.
- W2999298927 hasConcept C502942594 @default.
- W2999298927 hasConcept C526805850 @default.
- W2999298927 hasConcept C55493867 @default.
- W2999298927 hasConcept C62112901 @default.
- W2999298927 hasConcept C71924100 @default.
- W2999298927 hasConcept C86803240 @default.
- W2999298927 hasConceptScore W2999298927C104317684 @default.