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- W2999317444 abstract "Abstract In mammalian females, the transition between quiescent primordial follicles and follicular development is critical for maintaining ovarian function and reproductive longevity. In primary oocytes of mouse quiescent primordial follicles, Golgi complexes are organized into a spherical structure, the Balbiani body. Here, we show that the structure of the B-body is maintained by microtubules and actin. The B-body stores mRNA-capping enzyme and 597 mRNAs associated with mRNA-decapping enzyme 1A. Proteins encoded by these mRNAs function in enzyme binding, cellular component organization and packing of telomere ends. Pharmacological disassembly of the B-body triggers translation of stored mRNAs and activates primordial follicles in culture and in vivo mouse model. Thus, primordial follicle quiescence is maintained by the B-body, and translationally inactive B-body-stored mRNAs may be regulated by 5’-capping." @default.
- W2999317444 created "2020-01-23" @default.
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- W2999317444 date "2020-01-18" @default.
- W2999317444 modified "2023-09-24" @default.
- W2999317444 title "The mouse Balbiani body maintains primordial follicle quiescence via RNA storage" @default.
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- W2999317444 doi "https://doi.org/10.1101/2020.01.17.911040" @default.
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