Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999348766> ?p ?o ?g. }
- W2999348766 endingPage "e0226021" @default.
- W2999348766 startingPage "e0226021" @default.
- W2999348766 abstract "Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder currently affecting 45 million people worldwide, ranking as the 6th highest cause of death. Throughout the development and progression of AD, over 90% of patients display behavioral and psychological symptoms of dementia (BPSD), with some of these symptoms occurring before memory deficits and therefore serving as potential early predictors of AD-related cognitive decline. However, the biochemical links between AD and BPSD are not known. In this study, we explored the molecular interactions between AD and BPSD using protein-protein interaction (PPI) networks built from OMIM (Online Mendelian Inheritance in Man) genes that were related to AD and two distinct BPSD domains, the Affective Domain and the Hyperactivity, Impulsivity, Disinhibition, and Aggression (HIDA) Domain. Our results yielded 8 unique proteins for the Affective Domain (RHOA, GRB2, PIK3R1, HSPA4, HSP90AA1, GSK3beta, PRKCZ, and FYN), 5 unique proteins for the HIDA Domain (LRP1, EGFR, YWHAB, SUMO1, and EGR1), and 6 shared proteins between both BPSD domains (APP, UBC, ELAV1, YWHAZ, YWHAE, and SRC) and AD. These proteins might suggest specific targets and pathways that are involved in the pathogenesis of these BPSD domains in AD." @default.
- W2999348766 created "2020-01-23" @default.
- W2999348766 creator A5001702447 @default.
- W2999348766 creator A5015580680 @default.
- W2999348766 creator A5046675486 @default.
- W2999348766 creator A5053390290 @default.
- W2999348766 creator A5061006840 @default.
- W2999348766 date "2020-01-17" @default.
- W2999348766 modified "2023-09-26" @default.
- W2999348766 title "Protein-protein interactions underlying the behavioral and psychological symptoms of dementia (BPSD) and Alzheimer’s disease" @default.
- W2999348766 cites W1167899977 @default.
- W2999348766 cites W1480602442 @default.
- W2999348766 cites W1481130297 @default.
- W2999348766 cites W1541377218 @default.
- W2999348766 cites W1542326652 @default.
- W2999348766 cites W1588890655 @default.
- W2999348766 cites W1611407165 @default.
- W2999348766 cites W1847744149 @default.
- W2999348766 cites W1910379468 @default.
- W2999348766 cites W1958777380 @default.
- W2999348766 cites W1965828393 @default.
- W2999348766 cites W1966238197 @default.
- W2999348766 cites W1966349225 @default.
- W2999348766 cites W1971199242 @default.
- W2999348766 cites W1973160124 @default.
- W2999348766 cites W1973855353 @default.
- W2999348766 cites W1975350815 @default.
- W2999348766 cites W1976345822 @default.
- W2999348766 cites W1978714931 @default.
- W2999348766 cites W1979728352 @default.
- W2999348766 cites W1982373527 @default.
- W2999348766 cites W1984799320 @default.
- W2999348766 cites W1987521153 @default.
- W2999348766 cites W1989036097 @default.
- W2999348766 cites W1989347577 @default.
- W2999348766 cites W1990505622 @default.
- W2999348766 cites W1990752558 @default.
- W2999348766 cites W1992594876 @default.
- W2999348766 cites W1994085255 @default.
- W2999348766 cites W1997165485 @default.
- W2999348766 cites W1998628114 @default.
- W2999348766 cites W1999233676 @default.
- W2999348766 cites W2001405361 @default.
- W2999348766 cites W2001822060 @default.
- W2999348766 cites W2009142034 @default.
- W2999348766 cites W2011373732 @default.
- W2999348766 cites W2014593683 @default.
- W2999348766 cites W2014904526 @default.
- W2999348766 cites W2015153490 @default.
- W2999348766 cites W2015602829 @default.
- W2999348766 cites W2015775451 @default.
- W2999348766 cites W2020301095 @default.
- W2999348766 cites W2022532556 @default.
- W2999348766 cites W2022580514 @default.
- W2999348766 cites W2023527463 @default.
- W2999348766 cites W2023675574 @default.
- W2999348766 cites W2026622112 @default.
- W2999348766 cites W2030602441 @default.
- W2999348766 cites W2031024728 @default.
- W2999348766 cites W2032925606 @default.
- W2999348766 cites W2035015498 @default.
- W2999348766 cites W2039900537 @default.
- W2999348766 cites W2040793789 @default.
- W2999348766 cites W2047122396 @default.
- W2999348766 cites W2047427096 @default.
- W2999348766 cites W2051218736 @default.
- W2999348766 cites W2052742260 @default.
- W2999348766 cites W2056613924 @default.
- W2999348766 cites W2059057473 @default.
- W2999348766 cites W2060420002 @default.
- W2999348766 cites W2065019245 @default.
- W2999348766 cites W2067381980 @default.
- W2999348766 cites W2070301080 @default.
- W2999348766 cites W2071422768 @default.
- W2999348766 cites W2073918272 @default.
- W2999348766 cites W2079388718 @default.
- W2999348766 cites W2084666034 @default.
- W2999348766 cites W2086355707 @default.
- W2999348766 cites W2087102845 @default.
- W2999348766 cites W2088861514 @default.
- W2999348766 cites W2093486595 @default.
- W2999348766 cites W2093589399 @default.
- W2999348766 cites W2093932385 @default.
- W2999348766 cites W2095445167 @default.
- W2999348766 cites W2098656855 @default.
- W2999348766 cites W2102575773 @default.
- W2999348766 cites W2107013935 @default.
- W2999348766 cites W2109691697 @default.
- W2999348766 cites W2110684048 @default.
- W2999348766 cites W2112077456 @default.
- W2999348766 cites W2112329962 @default.
- W2999348766 cites W2116236374 @default.
- W2999348766 cites W2120296399 @default.
- W2999348766 cites W2123250120 @default.
- W2999348766 cites W2126155954 @default.
- W2999348766 cites W2126216247 @default.
- W2999348766 cites W2129605195 @default.
- W2999348766 cites W2130790725 @default.