Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999353742> ?p ?o ?g. }
- W2999353742 endingPage "105461" @default.
- W2999353742 startingPage "105461" @default.
- W2999353742 abstract "Organophosphate esters (OPEs) are a class of alternative replacements for polybrominated diphenyl ethers. In vitro and in vivo studies suggested that OPEs may disrupt the homeostasis of sex steroid hormones. However, human evidence in children and adolescents is limited. We conducted a cross-sectional analysis of the associations between OPE biomarkers and sex steroid hormones among children (6–11 years) and adolescents (12–19 years) in the U.S. National Health and Nutrition Examination Survey, 2013–2014. Participants aged 6–19 years who had available data on urinary OPE metabolites, serum sex hormones [total testosterone (TT), estradiol (E2)] and sex hormone binding globulin (SHBG) were included (n = 544). Free androgen index (FAI) calculated as TT divided by SHBG and a ratio of TT to E2 (TT/E2) were generated. Five urinary OPE metabolites were examined. A constructed puberty status was defined as either high steroid hormone levels (TT ≥ 50 ng/dL in males and E2 ≥ 20 pg/ml in females) or onset of menarche. Multiple linear regression and weighted quantile sum (WQS) regression analyses stratified by sex-age and sex-puberty-status groups were conducted to examine the associations of OPE metabolites and its mixture with sex hormone levels. After adjusting for covariates, dibutyl phosphate (DBUP) and dibutyl phosphate (DPHP) were significantly inversely associated with TT (or FAI) and E2; DBUP was negatively associated with SHBG; and DPHP was positively associated with SHBG and TT/E2 in female adolescents. In male adolescents, we observed monotonic negative associations of bis(1,3-dichloro-2-propyl) phosphate (BDCPP), DBUP or DPHP with TT (or FAI) and E2, and positive associations of BDCPP and DPHP with SHBG. Among adolescents, the OPEs index was negatively associated with TT [WQS beta = −0.29 (95% confidence interval: −0.51, −0.07) in males and −0.15 (−0.28, −0.01) in females ], FAI [−0.46 (−0.71, −0.2) in males and −0.23 (−0.41, −0.05) in females] and E2 [−0.25 (−0.41, −0.1) in males and −0.33 (−0.59, −0.08) in females], with stronger associations with TT and FAI in males and a slightly stronger association with E2 in females. In addition, the OPEs index presented a comparable positive association with SHBG in both sexes of adolescents. In contrast, significant associations of individual OPE metabolites or OPEs index with sex hormones were sparse in children. Results by sex-puberty status in single pollutant and WQS regression analyses presented a similar pattern, where most of the significant associations were limited to the pubertal individuals. Of note, stronger inverse associations of the OPEs index with TT and FAI remained in pubertal boys. But the association between the OPEs index and E2 was non-significant in pubertal girls, and only in pubertal boys did the OPEs index show a significant and stronger inverse association with E2. Exposure to OPEs, either individually or as a mixture, was associated with decreased levels of certain sex steroid hormones (TT, FAI, and E2) and increased levels of SHBG in adolescents or pubertal individuals, with the associations presenting somewhat sex-dependent pattern. However, there is little evidence of the significant associations in children or prepubescent ones. Given the cross-sectional nature of the analysis, our findings need further confirmation." @default.
- W2999353742 created "2020-01-23" @default.
- W2999353742 creator A5000441533 @default.
- W2999353742 creator A5030300141 @default.
- W2999353742 creator A5048366638 @default.
- W2999353742 creator A5060943605 @default.
- W2999353742 creator A5063088081 @default.
- W2999353742 creator A5072334257 @default.
- W2999353742 creator A5090655358 @default.
- W2999353742 date "2020-03-01" @default.
- W2999353742 modified "2023-10-17" @default.
- W2999353742 title "Associations between organophosphate esters and sex hormones among 6–19-year old children and adolescents in NHANES 2013–2014" @default.
- W2999353742 cites W1764086527 @default.
- W2999353742 cites W1964043583 @default.
- W2999353742 cites W1968156993 @default.
- W2999353742 cites W1974487890 @default.
- W2999353742 cites W1976280302 @default.
- W2999353742 cites W1985336009 @default.
- W2999353742 cites W1985370990 @default.
- W2999353742 cites W1989674032 @default.
- W2999353742 cites W1997685083 @default.
- W2999353742 cites W1999414566 @default.
- W2999353742 cites W2007917434 @default.
- W2999353742 cites W2013431689 @default.
- W2999353742 cites W2013438876 @default.
- W2999353742 cites W2038699706 @default.
- W2999353742 cites W2051293765 @default.
- W2999353742 cites W2052827499 @default.
- W2999353742 cites W2061828456 @default.
- W2999353742 cites W2068197014 @default.
- W2999353742 cites W2069356726 @default.
- W2999353742 cites W2085303838 @default.
- W2999353742 cites W2086662317 @default.
- W2999353742 cites W2094313314 @default.
- W2999353742 cites W2141380411 @default.
- W2999353742 cites W2145141579 @default.
- W2999353742 cites W2147827078 @default.
- W2999353742 cites W2148692216 @default.
- W2999353742 cites W2155797089 @default.
- W2999353742 cites W2163064437 @default.
- W2999353742 cites W2171543582 @default.
- W2999353742 cites W2223341823 @default.
- W2999353742 cites W2259490539 @default.
- W2999353742 cites W2264508110 @default.
- W2999353742 cites W2265634200 @default.
- W2999353742 cites W2321635716 @default.
- W2999353742 cites W2557162393 @default.
- W2999353742 cites W2584715938 @default.
- W2999353742 cites W2752457825 @default.
- W2999353742 cites W2767556821 @default.
- W2999353742 cites W2770580856 @default.
- W2999353742 cites W2799454523 @default.
- W2999353742 cites W2887209580 @default.
- W2999353742 cites W2898851374 @default.
- W2999353742 cites W2899767286 @default.
- W2999353742 cites W2903162316 @default.
- W2999353742 cites W2904347942 @default.
- W2999353742 cites W2923395739 @default.
- W2999353742 cites W2936670974 @default.
- W2999353742 cites W2939900361 @default.
- W2999353742 cites W655424900 @default.
- W2999353742 doi "https://doi.org/10.1016/j.envint.2020.105461" @default.
- W2999353742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31931349" @default.
- W2999353742 hasPublicationYear "2020" @default.
- W2999353742 type Work @default.
- W2999353742 sameAs 2999353742 @default.
- W2999353742 citedByCount "57" @default.
- W2999353742 countsByYear W29993537422020 @default.
- W2999353742 countsByYear W29993537422021 @default.
- W2999353742 countsByYear W29993537422022 @default.
- W2999353742 countsByYear W29993537422023 @default.
- W2999353742 crossrefType "journal-article" @default.
- W2999353742 hasAuthorship W2999353742A5000441533 @default.
- W2999353742 hasAuthorship W2999353742A5030300141 @default.
- W2999353742 hasAuthorship W2999353742A5048366638 @default.
- W2999353742 hasAuthorship W2999353742A5060943605 @default.
- W2999353742 hasAuthorship W2999353742A5063088081 @default.
- W2999353742 hasAuthorship W2999353742A5072334257 @default.
- W2999353742 hasAuthorship W2999353742A5090655358 @default.
- W2999353742 hasBestOaLocation W29993537421 @default.
- W2999353742 hasConcept C126322002 @default.
- W2999353742 hasConcept C134018914 @default.
- W2999353742 hasConcept C178790620 @default.
- W2999353742 hasConcept C185592680 @default.
- W2999353742 hasConcept C2777911890 @default.
- W2999353742 hasConcept C2779279991 @default.
- W2999353742 hasConcept C2779874844 @default.
- W2999353742 hasConcept C2779938979 @default.
- W2999353742 hasConcept C2780902042 @default.
- W2999353742 hasConcept C2780990795 @default.
- W2999353742 hasConcept C2908647359 @default.
- W2999353742 hasConcept C30092816 @default.
- W2999353742 hasConcept C42407357 @default.
- W2999353742 hasConcept C71315377 @default.
- W2999353742 hasConcept C71924100 @default.
- W2999353742 hasConcept C82685317 @default.
- W2999353742 hasConcept C99454951 @default.
- W2999353742 hasConceptScore W2999353742C126322002 @default.