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- W2999378215 abstract "We often see that clinical and demographic characteristics of real-world studies (RWS) do not differ from patients included in randomized controlled trials (RCT).to compare clinical and demographic aspects of patients included in RCT and RWS that evaluated new disease modifying treatment in multiple sclerosis (MS).a systematic non-language-restricted literature search of RCT and RWS that evaluated new disease modifying treatments (natalizumab, alemtuzumab, ocrelizumab, fingolimod, teriflunomide, dimethyl fumarate and cladribine) from January 2005 to January 2019. Demographic and clinical data were extracted, described and compared.18 RCT and 73 RWS were included. We found no differences in clinical and demographic aspects between RCT and RWS except in the frequency of naïve patients included in RCT vs. RWS 65.6% (95%CI 52-74) vs. 36.4% (95%CI 21-46), respectively, (p = 0.013) at study entry, as well as for the inclusion of patients that used previous treatment 34.4% (95%CI 22-41) vs. 63.6% (95%CI 53-74) in RCT and RWS, respectively,(p = 0.007) at study entry.We did not observe significant differences in most clinical and demographic aspects of included patients in RCT and RWS. Studies that include the full spectrum of MS patients followed in clinical practice are needed." @default.
- W2999378215 created "2020-01-23" @default.
- W2999378215 creator A5027171153 @default.
- W2999378215 creator A5036236307 @default.
- W2999378215 creator A5042670252 @default.
- W2999378215 creator A5050236099 @default.
- W2999378215 creator A5081701168 @default.
- W2999378215 date "2020-04-01" @default.
- W2999378215 modified "2023-10-01" @default.
- W2999378215 title "Do clinical trials for new disease modifying treatments include real world patients with multiple sclerosis?" @default.
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