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- W2999462757 abstract "Abstract During Drosophila oogenesis, the localization and translational regulation of maternal transcripts relies on RNA-binding proteins (RBPs). Many of these RBPs localize several mRNAs and may have additional direct interaction partners to regulate their functions. Using immunoprecipitation from whole Drosophila ovaries coupled to mass spectrometry, we examined protein-protein associations of 6 GFP-tagged RBPs expressed at physiological levels. Analysis of the interaction network and further validation in human cells allowed us to identify 26 previously unknown associations, besides recovering several well characterized interactions. We identified interactions between RBPs and several splicing factors, providing links between nuclear and cytoplasmic events of mRNA regulation. Additionally, components of the translational and RNA decay machineries were selectively co-purified with some baits, suggesting a mechanism for how RBPs may regulate maternal transcripts. Given the evolutionary conservation of the studied RBPs, the interaction network presented here provides the foundation for future functional and structural studies of mRNA localization across metazoans." @default.
- W2999462757 created "2020-01-23" @default.
- W2999462757 creator A5002310732 @default.
- W2999462757 creator A5027454363 @default.
- W2999462757 creator A5062230417 @default.
- W2999462757 creator A5079814195 @default.
- W2999462757 creator A5085238149 @default.
- W2999462757 date "2020-01-09" @default.
- W2999462757 modified "2023-10-14" @default.
- W2999462757 title "An interaction network of RNA-binding proteins involved in<i>Drosophila</i>oogenesis" @default.
- W2999462757 cites W1418224 @default.
- W2999462757 cites W1867346435 @default.
- W2999462757 cites W1956457548 @default.
- W2999462757 cites W1964445614 @default.
- W2999462757 cites W1967802273 @default.
- W2999462757 cites W1969353942 @default.
- W2999462757 cites W1973763480 @default.
- W2999462757 cites W1974434328 @default.
- W2999462757 cites W1974822125 @default.
- W2999462757 cites W1979021029 @default.
- W2999462757 cites W1980075211 @default.
- W2999462757 cites W1981153918 @default.
- W2999462757 cites W1981762151 @default.
- W2999462757 cites W1986313893 @default.
- W2999462757 cites W1986656413 @default.
- W2999462757 cites W1991272741 @default.
- W2999462757 cites W1995786503 @default.
- W2999462757 cites W2002256260 @default.
- W2999462757 cites W2006621496 @default.
- W2999462757 cites W2009747268 @default.
- W2999462757 cites W2010411090 @default.
- W2999462757 cites W2010520098 @default.
- W2999462757 cites W2011340277 @default.
- W2999462757 cites W2014791263 @default.
- W2999462757 cites W2016437316 @default.
- W2999462757 cites W2019277035 @default.
- W2999462757 cites W2020320730 @default.
- W2999462757 cites W2020700519 @default.
- W2999462757 cites W2021006884 @default.
- W2999462757 cites W2026657651 @default.
- W2999462757 cites W2028191209 @default.
- W2999462757 cites W2028633196 @default.
- W2999462757 cites W2029956878 @default.
- W2999462757 cites W2030393062 @default.
- W2999462757 cites W2032171766 @default.
- W2999462757 cites W2032603175 @default.
- W2999462757 cites W2036321220 @default.
- W2999462757 cites W2043495620 @default.
- W2999462757 cites W2044907561 @default.
- W2999462757 cites W2047040065 @default.
- W2999462757 cites W2048581195 @default.
- W2999462757 cites W2049255037 @default.
- W2999462757 cites W2051862923 @default.
- W2999462757 cites W2052533578 @default.
- W2999462757 cites W2052595458 @default.
- W2999462757 cites W2055753459 @default.
- W2999462757 cites W2057479447 @default.
- W2999462757 cites W2058318950 @default.
- W2999462757 cites W2060061304 @default.
- W2999462757 cites W2060994023 @default.
- W2999462757 cites W2063173391 @default.
- W2999462757 cites W2071697093 @default.
- W2999462757 cites W2072245647 @default.
- W2999462757 cites W2073094091 @default.
- W2999462757 cites W2073146686 @default.
- W2999462757 cites W2073918293 @default.
- W2999462757 cites W2080752012 @default.
- W2999462757 cites W2080924644 @default.
- W2999462757 cites W2083489721 @default.
- W2999462757 cites W2085499501 @default.
- W2999462757 cites W2087543106 @default.
- W2999462757 cites W2089897307 @default.
- W2999462757 cites W2090988645 @default.
- W2999462757 cites W2091638660 @default.
- W2999462757 cites W2091978286 @default.
- W2999462757 cites W2092048230 @default.
- W2999462757 cites W2098205601 @default.
- W2999462757 cites W2101060338 @default.
- W2999462757 cites W2104377074 @default.
- W2999462757 cites W2105068295 @default.
- W2999462757 cites W2105513224 @default.
- W2999462757 cites W2107887850 @default.
- W2999462757 cites W2109273557 @default.
- W2999462757 cites W2111069555 @default.
- W2999462757 cites W2111166800 @default.
- W2999462757 cites W2112847380 @default.
- W2999462757 cites W2116438422 @default.
- W2999462757 cites W2117514979 @default.
- W2999462757 cites W2117936467 @default.
- W2999462757 cites W2121790667 @default.
- W2999462757 cites W2125910575 @default.
- W2999462757 cites W2126294535 @default.
- W2999462757 cites W2129827413 @default.
- W2999462757 cites W2131681506 @default.
- W2999462757 cites W2132888497 @default.
- W2999462757 cites W2133465414 @default.
- W2999462757 cites W2136921460 @default.
- W2999462757 cites W2140102385 @default.
- W2999462757 cites W2142603983 @default.
- W2999462757 cites W2143647123 @default.