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- W2999463932 abstract "Evolution and selection have shaped diverse immune systems throughout phylogeny, the vast majority of which remain unexplored. Botryllus schlosseri is a colonial tunicate, a sister group to vertebrates, that develops as a chordate, then metamorphoses to an asexually reproductive invertebrate that every week makes the same body plan from budded stem cells. Genetically distinct B. schlosseri colonies can fuse to form a chimera, or reject each other based on allogeneic recognition. In chimeras, circulating germline and somatic stem cells participate in development; stem cells compete in all individuals in the fused colonies, with rejection preventing germline parasitism. Here we review the isolation and characterization of B. schlosseri hematopoietic stem cells (HSC) and their niches, and the role of the immune effector cells in allorecognition." @default.
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- W2999463932 date "2020-02-01" @default.
- W2999463932 modified "2023-10-18" @default.
- W2999463932 title "Evolutionary perspective on the hematopoietic system through a colonial chordate: allogeneic immunity and hematopoiesis" @default.
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- W2999463932 doi "https://doi.org/10.1016/j.coi.2019.12.006" @default.
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