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- W2999479529 abstract "ABSTRACT Background HRLPC has an increased risk of positive margins and recurrence after local treatment. Neoadjuvant docetaxel has not shown to increase the percentage of pathological complete responses (pRCs) respect to hormone-therapy alone. In a previous phase II trial of neoadjuvant D plus CAB in patients with HRLPC we reported a 6% pRCs. (Mellado B, Br J Cancer 2009). We proposed that the molecular analysis of residual tumor cells after D + CAB may help to identify molecular mechanisms of treatment resistance. Methods 93 genes potentially involved in D resistance were selected from a previous molecular study of our group (Marin-Aguilera M, Mol Cancer Ther 2012). Gene transcriptional levels were analyzed by using Taqman low density arrays in 28 formalin-fixed paraffin-embedded (FFPE) tumors from HRLPC patients treated with D + CAG prior radical prostatectomy, and in 36 HRLPC patients who underwent radical prostatectomy without neoadjuvant therapy. GUSB housekeeping gene was the reference for normalization. Gene expression determination was performed with RQ Manager Software for manual data analysis. Results Differential gene expression of 67.7% (63 of 93 analyzed genes) was found in neoadjuvant treated tumors versus samples without neoadjuvant treatment (P Conclusions Residual tumor cells in prostatectomy specimens after neoadjuvant hormone- and chemotherapy treatment already exhibits a gene expression profile that may be involved in hormone/chemo resistant phenotype. Disclosure All authors have declared no conflicts of interest." @default.
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- W2999479529 date "2012-09-01" @default.
- W2999479529 modified "2023-10-07" @default.
- W2999479529 title "Molecular Profiling of High-Risk Localized Prostate Cancer (HRLPC) Treated With Docetaxel (D) and Complete Androgen Blockade (CAB) Prior To Radical Prostatectomy" @default.
- W2999479529 doi "https://doi.org/10.1016/s0923-7534(20)34226-5" @default.
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