FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999488889> ?p ?o ?g. }

• W2999488889 endingPage "1158" @default.
• W2999488889 startingPage "1150" @default.
• W2999488889 abstract "Background. Localization of inflammatory stimuli may direct lung allografts to different phenotypes of chronic dysfunction, such as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). We hypothesized that airway stimulation with lipopolysaccharide (LPS) in rats leads to airway-centered inflammation similar to human BOS. Methods. Rat left lung transplantation was conducted (donor: Brown Norway, recipient: Lewis). Allotransplant recipients received cyclosporine A (CsA) until postoperative day 56 with airway instillation of LPS (Allo-LPS, n = 8), phosphate buffered saline (Allo-PBS, n = 5) from days 35 to 46 (3 times a wk), or no further treatment (n = 4). Some allotransplant recipients received CsA until day 14 and were immunosuppression free after day 15 until day 56. Bronchial and pleural fibrosis were semiquantified; alveolar fibrosis was evaluated with a histological scale. Results. The Allo-LPS group had significantly increased International Society for Heart and Lung Transplantation rejection grades (grade A, P = 0.005; grade B, P = 0.004), bronchial obstructive proportion (0.34 ± 0.04% [Allo-LPS] versus 0.11 ± 0.04% [Allo-PBS], P = 0.006), and airway resistance (3.05 ± 1.78 cm H 2 O·s/mL [Allo-LPS] versus 0.83 ± 0.58 cm H 2 O·s/mL [Allo-PBS], P = 0.007) compared with other groups. Allotransplant recipients that underwent a short course of CsA developed RAS-like fibrosis involving the airways, alveoli, and pleura. Conclusions. Airway instillation of LPS in allografts under immunosuppression resulted in BOS-like airway-centered inflammation and fibrosis distinct from RAS-like diffuse fibrosis, which was induced by a shortened course of immunosuppression. We propose novel animal models for BOS and RAS after lung transplantation." @default.
• W2999488889 created "2020-01-23" @default.
• W2999488889 creator A5005194119 @default.
• W2999488889 creator A5014487983 @default.
• W2999488889 creator A5015740193 @default.
• W2999488889 creator A5017146720 @default.
• W2999488889 creator A5032553596 @default.
• W2999488889 creator A5050627437 @default.
• W2999488889 creator A5053305214 @default.
• W2999488889 creator A5065103395 @default.
• W2999488889 creator A5065240547 @default.
• W2999488889 creator A5071175870 @default.
• W2999488889 creator A5078102009 @default.
• W2999488889 creator A5088395139 @default.
• W2999488889 creator A5089403750 @default.
• W2999488889 date "2020-06-01" @default.
• W2999488889 modified "2023-10-04" @default.
• W2999488889 title "LPS-induced Airway-centered Inflammation Leading to BOS-like Airway Remodeling Distinct From RAS-like Fibrosis in Rat Lung Transplantation" @default.
• W2999488889 cites W1971892025 @default.
• W2999488889 cites W1980972771 @default.
• W2999488889 cites W1995646773 @default.
• W2999488889 cites W2001518113 @default.
• W2999488889 cites W2010841805 @default.
• W2999488889 cites W2016632860 @default.
• W2999488889 cites W2032764486 @default.
• W2999488889 cites W2036108273 @default.
• W2999488889 cites W2039688361 @default.
• W2999488889 cites W2051009082 @default.
• W2999488889 cites W2052266385 @default.
• W2999488889 cites W2055953496 @default.
• W2999488889 cites W2075400164 @default.
• W2999488889 cites W2076265128 @default.
• W2999488889 cites W2081710302 @default.
• W2999488889 cites W2102601462 @default.
• W2999488889 cites W2119734002 @default.
• W2999488889 cites W2132931252 @default.
• W2999488889 cites W2140667296 @default.
• W2999488889 cites W2169692571 @default.
• W2999488889 cites W2407610499 @default.
• W2999488889 cites W2498098048 @default.
• W2999488889 cites W2550669699 @default.
• W2999488889 cites W2552201507 @default.
• W2999488889 cites W2587957924 @default.
• W2999488889 cites W2620225677 @default.
• W2999488889 cites W2747271331 @default.
• W2999488889 cites W2933321059 @default.
• W2999488889 cites W2933468399 @default.
• W2999488889 cites W4255154235 @default.
• W2999488889 doi "https://doi.org/10.1097/tp.0000000000003097" @default.
• W2999488889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31929420" @default.
• W2999488889 hasPublicationYear "2020" @default.
• W2999488889 type Work @default.
• W2999488889 sameAs 2999488889 @default.
• W2999488889 citedByCount "8" @default.
• W2999488889 countsByYear W29994888892020 @default.
• W2999488889 countsByYear W29994888892022 @default.
• W2999488889 countsByYear W29994888892023 @default.
• W2999488889 crossrefType "journal-article" @default.
• W2999488889 hasAuthorship W2999488889A5005194119 @default.
• W2999488889 hasAuthorship W2999488889A5014487983 @default.
• W2999488889 hasAuthorship W2999488889A5015740193 @default.
• W2999488889 hasAuthorship W2999488889A5017146720 @default.
• W2999488889 hasAuthorship W2999488889A5032553596 @default.
• W2999488889 hasAuthorship W2999488889A5050627437 @default.
• W2999488889 hasAuthorship W2999488889A5053305214 @default.
• W2999488889 hasAuthorship W2999488889A5065103395 @default.
• W2999488889 hasAuthorship W2999488889A5065240547 @default.
• W2999488889 hasAuthorship W2999488889A5071175870 @default.
• W2999488889 hasAuthorship W2999488889A5078102009 @default.
• W2999488889 hasAuthorship W2999488889A5088395139 @default.
• W2999488889 hasAuthorship W2999488889A5089403750 @default.
• W2999488889 hasConcept C105922876 @default.
• W2999488889 hasConcept C126322002 @default.
• W2999488889 hasConcept C142724271 @default.
• W2999488889 hasConcept C203014093 @default.
• W2999488889 hasConcept C2776739411 @default.
• W2999488889 hasConcept C2776914184 @default.
• W2999488889 hasConcept C2777714996 @default.
• W2999488889 hasConcept C2780252810 @default.
• W2999488889 hasConcept C2780559512 @default.
• W2999488889 hasConcept C2781448352 @default.
• W2999488889 hasConcept C2911091166 @default.
• W2999488889 hasConcept C42219234 @default.
• W2999488889 hasConcept C71924100 @default.
• W2999488889 hasConcept C90924648 @default.
• W2999488889 hasConceptScore W2999488889C105922876 @default.
• W2999488889 hasConceptScore W2999488889C126322002 @default.
• W2999488889 hasConceptScore W2999488889C142724271 @default.
• W2999488889 hasConceptScore W2999488889C203014093 @default.
• W2999488889 hasConceptScore W2999488889C2776739411 @default.
• W2999488889 hasConceptScore W2999488889C2776914184 @default.
• W2999488889 hasConceptScore W2999488889C2777714996 @default.
• W2999488889 hasConceptScore W2999488889C2780252810 @default.
• W2999488889 hasConceptScore W2999488889C2780559512 @default.
• W2999488889 hasConceptScore W2999488889C2781448352 @default.
• W2999488889 hasConceptScore W2999488889C2911091166 @default.
• W2999488889 hasConceptScore W2999488889C42219234 @default.
• W2999488889 hasConceptScore W2999488889C71924100 @default.

• next