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• W2999576469 abstract "Abstract Objective The purpose of the present study was to characterize the composition of the salivary microbiota and quantify salivary levels of inflammation‐related proteins (neutrophil gelatinase‐associated lipocalin [NGAL] and transferrin) in patients with psoriasis and compare data to those obtained in patients with periodontitis and orally healthy controls, respectively. Materials and methods Stimulated saliva samples from patients with psoriasis ( n = 27), patients with periodontitis ( n = 58), and orally healthy controls ( n = 52) were characterized by means of next‐generation sequencing of the 16S rRNA gene. Salivary levels of NGAL and transferrin were quantified using immunoassays. Results Linear discriminant effect size analysis showed that 52 (22 psoriasis‐associated and 30 periodontitis‐associated) and 21 (8 psoriasis‐associated and 13 orally healthy control‐associated) bacterial taxa differentiated the salivary microbiota in patients with psoriasis from that of patients with periodontitis and orally healthy controls, respectively. Significantly lower mean salivary levels of NGAL (psoriasis: 996 [std. error 320], periodontitis: 2,072 [295], orally healthy controls: 2,551 [345] ng/ml, p < .0001) and transferrin (psoriasis: 4.37 [0.92], periodontitis: 7.25 [0.88], orally healthy controls: 10.02 [0.94] ng/ml, p < .0001) were identified in patients with psoriasis. Conclusions Psoriasis associates with characteristics of the salivary microbiota and salivary levels of inflammation‐related proteins, which are different from characteristics in patients with periodontitis and orally healthy controls, respectively." @default.
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• W2999576469 date "2020-01-28" @default.
• W2999576469 modified "2023-10-16" @default.
• W2999576469 title "Salivary microbiota and inflammation‐related proteins in patients with psoriasis" @default.
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• W2999576469 doi "https://doi.org/10.1111/odi.13277" @default.
• W2999576469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7188313" @default.
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