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- W2999579971 abstract "Cysteinyl cathepsins are lysosomal/endosomal proteases that mediate bulk protein degradation in these intracellular acidic compartments. Yet, studies indicate that these proteases also appear in the nucleus, nuclear membrane, cytosol, plasma membrane, and extracellular space. Patients with cardiovascular diseases (CVD) show increased levels of cathepsins in the heart, aorta, and plasma. Plasma cathepsins often serve as biomarkers or risk factors of CVD. In aortic diseases, such as atherosclerosis and abdominal aneurysms, cathepsins play pathogenic roles, but many of the same cathepsins are cardioprotective in hypertensive, hypertrophic, and infarcted hearts. During the development of CVD, cathepsins are regulated by inflammatory cytokines, growth factors, hypertensive stimuli, oxidative stress, and many others. Cathepsin activities in inflammatory molecule activation, immunity, cell migration, cholesterol metabolism, neovascularization, cell death, cell signaling, and tissue fibrosis all contribute to CVD and are reviewed in this article in memory of Dr. Nobuhiko Katunuma for his contribution to the field." @default.
- W2999579971 created "2020-01-23" @default.
- W2999579971 creator A5008097382 @default.
- W2999579971 creator A5025535213 @default.
- W2999579971 creator A5040193720 @default.
- W2999579971 creator A5070219423 @default.
- W2999579971 date "2020-04-01" @default.
- W2999579971 modified "2023-10-03" @default.
- W2999579971 title "Cysteinyl cathepsins in cardiovascular diseases" @default.
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