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• W2999592757 abstract "Propofol is a widely used intravenous anesthetic shown to exert a cardioprotective role against oxidative stress and ischemia/reperfusion injury in rat cardiac H9c2 cells. However, the regulatory mechanisms and functions of propofol in human cardiomyocytes remain unknown. The present study chemically induced hypoxia with cobalt chloride (CoCl2) to mimic cardiomyocyte ischemic injury in human cardiac AC16 and HCM cells. To investigate its underlying mechanisms, propofol was added to the cells before the chemical hypoxia phase. The present results suggested that, in response to hypoxia, mitochondrial membrane potential was lost, and cardiomyocyte viability and superoxide dismutase levels decreased. However, the present results showed that reactive oxygen species and malondialdehyde levels increased. The present results suggested that these effects were significantly reversed following propofol treatment. Additionally, the present results suggested that the protective effect of propofol against CoCl2-induced injury may be inhibited by the activation of the JNK signaling pathways. The present results indicated that propofol pre-treatment inhibited CoCl2-induced myocardial injury by preventing mitochondrial dysfunction, which may be partially due to the activation of the JNK signaling pathways. Therefore, propofol may exert anti-oxidative effects in human cardiac cells. The present results suggested that propofol may be used as a treatment for oxidative stress-related cardiac disorders." @default.
• W2999592757 created "2020-01-23" @default.
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• W2999592757 date "2020-01-08" @default.
• W2999592757 modified "2023-09-24" @default.
• W2999592757 title "Propofol protects human cardiac cells against chemical hypoxiainduced injury by regulating the JNK signaling pathways" @default.
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• W2999592757 doi "https://doi.org/10.3892/etm.2020.8440" @default.
• W2999592757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7027152" @default.
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